Shan Li-Li, Wang Yi-Lin, Qiao Tian-Ci, Bian Yue-Feng, Huo Ya-Jing, Guo Cen, Liu Qian-Yun, Yang Zi-Dong, Li Ze-Zhi, Liu Ming-Yuan, Han Yan
Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Georgetown Preparatory School, North Bethesda, MD, United States.
Front Neurol. 2022 Jul 8;13:938655. doi: 10.3389/fneur.2022.938655. eCollection 2022.
Cerebral small vessel disease (CSVD) is a clinical syndrome caused by pathological changes in small vessels. Anxiety is a common symptom of CSVD. Previous studies have reported the association between inflammatory factors and anxiety in other diseases, but this association in patients with CSVD remains uncovered. Our study aimed to investigate whether serum inflammatory factors correlated with anxiety in patients with CSVD.
A total of 245 CSVD patients confirmed using brain magnetic resonance imaging (MRI) were recruited from December 2019 to December 2021. Hamilton Anxiety Rating Scale (HAMA) was used to assess the anxiety symptoms of CSVD patients. Patients with HAMA scores ≥7 were considered to have anxiety symptoms. The serum levels of interleukin-1β (IL-1β), IL-2R, IL-6, IL-8, IL-10, tumor necrosis factor-α (TNF-α), serum amyloid A (SAA), C-reactive protein (CRP), high-sensitivity C-reactive protein (hs-CRP) and erythrocyte sedimentation rate (ESR) were detected. We compared levels of inflammatory factors between the anxiety and non-anxiety groups. Logistic regression analyses examined the correlation between inflammatory factors and anxiety symptoms. We further performed a gender subgroup analysis to investigate whether this association differed by gender.
In the fully adjusted multivariate logistic regression analysis model, we found that lower levels of IL-8 were linked to a higher risk of anxiety symptoms. Moreover, higher levels of SAA were linked to a lower risk of anxiety symptoms. Our study identified sex-specific effects, and the correlation between IL-8 and anxiety symptoms remained significant among males, while the correlation between SAA and anxiety symptoms remained significant among females.
In this study, we found a suggestive association between IL-8, SAA, and anxiety symptoms in CSVD participants. Furthermore, IL-8 and SAA may have a sex-specific relationship with anxiety symptoms.
脑小血管病（CSVD）是一种由小血管病理改变引起的临床综合征。焦虑是CSVD的常见症状。既往研究报道了炎症因子与其他疾病中焦虑的关联，但CSVD患者中的这种关联仍未被揭示。我们的研究旨在调查血清炎症因子是否与CSVD患者的焦虑相关。
2019年12月至2021年12月共招募了245例经脑磁共振成像（MRI）确诊的CSVD患者。采用汉密尔顿焦虑评定量表（HAMA）评估CSVD患者的焦虑症状。HAMA评分≥7分的患者被认为有焦虑症状。检测血清白细胞介素-1β（IL-1β）、IL-2R、IL-6、IL-8、IL-10、肿瘤坏死因子-α（TNF-α）、血清淀粉样蛋白A（SAA）、C反应蛋白（CRP）、高敏C反应蛋白（hs-CRP）和红细胞沉降率（ESR）水平。我们比较了焦虑组和非焦虑组的炎症因子水平。逻辑回归分析检验炎症因子与焦虑症状之间的相关性。我们进一步进行了性别亚组分析，以调查这种关联是否因性别而异。
在完全调整的多变量逻辑回归分析模型中，我们发现较低水平的IL-8与较高的焦虑症状风险相关。此外，较高水平的SAA与较低的焦虑症状风险相关。我们的研究发现了性别特异性效应，IL-8与焦虑症状之间的相关性在男性中仍然显著，而SAA与焦虑症状之间的相关性在女性中仍然显著。
在本研究中，我们发现CSVD参与者中IL-8、SAA与焦虑症状之间存在提示性关联。此外，IL-8和SAA可能与焦虑症状存在性别特异性关系。
