Nuclear organization and dynamics: The final Frontier for understanding genome regulation.
作者信息
Schirmer Eric C
机构信息
Institute of Cell Biology, University of Edinburgh, Edinburgh, United Kingdom.
出版信息
Front Cell Dev Biol. 2022 Jul 18;10:951875. doi: 10.3389/fcell.2022.951875. eCollection 2022.
Abstract
摘要
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Disruption Alters Radial Gene Positioning in Mouse Liver Leading to Metabolic Defects and Diabetes Characteristics.破坏改变了小鼠肝脏中基因的径向定位，导致代谢缺陷和糖尿病特征。
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A multistage sequencing strategy pinpoints novel candidate alleles for Emery-Dreifuss muscular dystrophy and supports gene misregulation as its pathomechanism.一种多阶段测序策略确定了 Emery-Dreifuss 肌营养不良症的新型候选等位基因，并支持基因调控失常作为其发病机制。
EBioMedicine. 2020 Jan;51:102587. doi: 10.1016/j.ebiom.2019.11.048. Epub 2019 Dec 17.
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Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis.肌肉核膜蛋白介导的组织特异性基因重定位增强了成肌过程中关键发育基因的抑制作用。
Mol Cell. 2016 Jun 16;62(6):834-847. doi: 10.1016/j.molcel.2016.04.035. Epub 2016 Jun 2.
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Emerin and histone deacetylase 3 (HDAC3) cooperatively regulate expression and nuclear positions of MyoD, Myf5, and Pax7 genes during myogenesis.弹力蛋白和组蛋白去乙酰化酶 3（HDAC3）在肌发生过程中协同调节 MyoD、Myf5 和 Pax7 基因的表达和核定位。
Chromosome Res. 2013 Dec;21(8):765-79. doi: 10.1007/s10577-013-9381-9. Epub 2013 Sep 24.
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DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina.DNA 序列依赖性的核纤层处染色质的区室化和沉默。
Cell. 2012 Jun 22;149(7):1474-87. doi: 10.1016/j.cell.2012.04.035.
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