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Front Cell Dev Biol. 2022 Jul 18;10:969178. doi: 10.3389/fcell.2022.969178. eCollection 2022.
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GMP-manufactured density gradient media for optimized mesenchymal stromal/stem cell isolation and expansion.GMP 制造的密度梯度介质，用于优化间充质基质/干细胞的分离和扩增。
Cytotherapy. 2010 Jul;12(4):466-77. doi: 10.3109/14653241003649510.
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Evaluation of GMP-compliant culture media for in vitro expansion of human bone marrow mesenchymal stromal cells.用于人骨髓间充质基质细胞体外扩增的符合药品生产质量管理规范的培养基的评估
Exp Hematol. 2016 Jun;44(6):508-18. doi: 10.1016/j.exphem.2016.02.004. Epub 2016 Feb 19.
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J Cardiol. 2019 Oct;74(4):304-312. doi: 10.1016/j.jjcc.2019.04.006. Epub 2019 May 18.
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Stem Cells Int. 2018 Apr 11;2018:4083921. doi: 10.1155/2018/4083921. eCollection 2018.
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Expert Rev Respir Med. 2021 Mar;15(3):301-324. doi: 10.1080/17476348.2021.1848555. Epub 2020 Nov 26.
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Tissue Eng Part B Rev. 2017 Oct;23(5):462-470. doi: 10.1089/ten.TEB.2016.0451. Epub 2017 Feb 28.
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Human platelet lysate in mesenchymal stromal cell expansion according to a GMP grade protocol: a cell factory experience.根据 GMP 级方案扩增间充质基质细胞中的人血小板裂解物：细胞工厂的经验。
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Therapeutic Properties of Mesenchymal Stromal/Stem Cells: The Need of Cell Priming for Cell-Free Therapies in Regenerative Medicine.间质基质/干细胞的治疗特性：再生医学中细胞无细胞治疗需要细胞预刺激。
Int J Mol Sci. 2021 Jan 14;22(2):763. doi: 10.3390/ijms22020763.

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Emerging Role of Mesenchymal Stromal Cell and Exosome Therapies in Treating Cognitive Impairment.间充质基质细胞和外泌体疗法在治疗认知障碍中的新兴作用
Pharmaceutics. 2025 Feb 20;17(3):284. doi: 10.3390/pharmaceutics17030284.
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Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword.多发性骨髓瘤患者骨髓微环境中的间充质基质细胞：一把双刃剑。
Cancer Cell Int. 2025 Mar 26;25(1):117. doi: 10.1186/s12935-025-03741-x.
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Cell Therapies for Acute Radiation Syndrome.细胞疗法治疗急性辐射综合征。
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Human Placental Mesenchymal Stem Cells and Derived Extracellular Vesicles Ameliorate Lung Injury in Acute Respiratory Distress Syndrome Murine Model.人胎盘间充质干细胞及其衍生的细胞外囊泡改善急性呼吸窘迫综合征小鼠模型的肺损伤。
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本文引用的文献

1
Point-of-care cell therapy manufacturing; it's not for everyone.即时细胞治疗生产；并非人人适用。
J Transl Med. 2022 Jan 15;20(1):34. doi: 10.1186/s12967-022-03238-5.
2
3D cell sheet structure augments mesenchymal stem cell cytokine production.3D细胞片层结构增强间充质干细胞细胞因子的产生。
Sci Rep. 2021 Apr 14;11(1):8170. doi: 10.1038/s41598-021-87571-7.
3
Human Mesenchymal Stromal Cell (MSC) Characteristics Vary Among Laboratories When Manufactured From the Same Source Material: A Report by the Cellular Therapy Team of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative.当从相同来源材料制备时，人间充质基质细胞（MSC）特性在不同实验室间存在差异：安全输血生物卓越性（BEST）协作组细胞治疗团队的报告
Front Cell Dev Biol. 2020 Jun 16;8:458. doi: 10.3389/fcell.2020.00458. eCollection 2020.
4
Trends in mesenchymal stem cell clinical trials 2004-2018: Is efficacy optimal in a narrow dose range?2004 - 2018年间间充质干细胞临床试验趋势：疗效在窄剂量范围内是否最佳？
Stem Cells Transl Med. 2020 Jan;9(1):17-27. doi: 10.1002/sctm.19-0202. Epub 2019 Dec 5.
5
Mesenchymal Stem Cells for Regenerative Medicine.间质干细胞在再生医学中的应用。
Cells. 2019 Aug 13;8(8):886. doi: 10.3390/cells8080886.
6
Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies.改善间充质基质细胞疗法疗效的启动方法。
Stem Cell Res Ther. 2019 May 2;10(1):131. doi: 10.1186/s13287-019-1224-y.
7
Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning.间质基质细胞分泌组：通过细胞预处理影响治疗潜力。
Front Immunol. 2018 Dec 4;9:2837. doi: 10.3389/fimmu.2018.02837. eCollection 2018.
8
Commercial Scale Manufacturing of Allogeneic Cell Therapy.异基因细胞疗法的商业化规模生产。
Front Med (Lausanne). 2018 Aug 22;5:233. doi: 10.3389/fmed.2018.00233. eCollection 2018.
9
The need to revisit the definition of mesenchymal and adult stem cells based on their functional attributes.有必要根据间充质和成人干细胞的功能属性重新定义它们。
Stem Cell Res Ther. 2018 Mar 27;9(1):78. doi: 10.1186/s13287-018-0833-1.
10
Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine.间质干细胞衍生的细胞外囊泡：再生医学的新前沿。
Stem Cell Res Ther. 2018 Mar 9;9(1):63. doi: 10.1186/s13287-018-0791-7.

Editorial: Mesenchymal Stromal Cells: Preclinical and Clinical Challenges.

作者信息

Oliva Joan, Pacini Simone, Canals Josep M, Lim Mayasari

机构信息

Department of Clinical Research, Emmaus Life Sciences, Torrance, CA, United States.

University of Pisa, Pisa, Italy.

出版信息

Front Cell Dev Biol. 2022 Jul 18;10:969178. doi: 10.3389/fcell.2022.969178. eCollection 2022.

DOI:10.3389/fcell.2022.969178
PMID:35923853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9339899/
Abstract
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