Zhang Lei, Zhang Yuan, Yu Fei, Li Xin, Gao Huijuan, Li Peifeng
Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Front Pharmacol. 2022 Jul 18;13:941123. doi: 10.3389/fphar.2022.941123. eCollection 2022.
Myocardial infarction (MI) is a serious heart disease that causes high mortality rate worldwide. Noncoding RNAs are widely involved in the pathogenesis of MI. Circular RNAs (circRNAs) are recently validated to be crucial modulators of MI. CircRNAs are circularized RNAs with covalently closed loops, which make them stable under various conditions. CircRNAs can function by different mechanisms, such as serving as sponges of microRNAs (miRNAs) and RNA-binding proteins (RBPs), regulating mRNA transcription, and encoding peptides. Among these mechanisms, sponging miRNAs/RBPs is the main pathway. In this paper, we systematically review the current knowledge on the properties and action modes of circRNAs, elaborate on the roles of the circRNA-miRNA/RBP network in MI, and explore the value of circRNAs in MI diagnosis and clinical therapies. CircRNAs are widely involved in MI. CircRNAs have many advantages, such as stability, specificity, and wide distribution, which imply that circRNAs have a great potential to act as biomarkers for MI diagnosis and prognosis.
心肌梗死（MI）是一种严重的心脏病，在全球范围内导致高死亡率。非编码RNA广泛参与心肌梗死的发病机制。环状RNA（circRNAs）最近被证实是心肌梗死的关键调节因子。CircRNAs是具有共价闭合环的环状RNA，这使得它们在各种条件下都很稳定。CircRNAs可以通过不同的机制发挥作用，例如作为微小RNA（miRNAs）和RNA结合蛋白（RBPs）的海绵，调节mRNA转录，以及编码肽。在这些机制中，充当miRNAs/RBPs的海绵是主要途径。在本文中，我们系统地综述了目前关于circRNAs的特性和作用模式的知识，阐述了circRNA-miRNA/RBP网络在心肌梗死中的作用，并探讨了circRNAs在心肌梗死诊断和临床治疗中的价值。CircRNAs广泛参与心肌梗死。CircRNAs具有许多优点，如稳定性、特异性和广泛分布，这意味着circRNAs有很大的潜力作为心肌梗死诊断和预后的生物标志物。
