Graduate School of Sports and Health Science, Fukuoka University, Fukuoka, Japan.
Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan.
Physiol Rep. 2022 Aug;10(15):e15420. doi: 10.14814/phy2.15420.
Exercise is restricted for individuals with reduced renal function because exercising reduces blood flow to the kidneys. Safe and effective exercise programs for individuals with reduced renal function have not yet been developed. We previously examined the relationship between exercise intensity and renal blood flow (RBF), revealing that moderate-intensity exercise did not reduce RBF. Determining the effects of exercise duration on RBF may have valuable clinical applications. The current study examined the effects of a single bout of continuous exercise at lactate threshold (LT) intensity on renal hemodynamics. Eight adult males participated in this study. Participants underwent 30 min of aerobic exercise at LT intensity using a cycle ergometer. Evaluation of renal hemodynamics was performed before and after exercise, in the recovery phase using ultrasound echo. Furthermore, blood and urine samplings were conducted before and after exercise, in the recovery phase. Compared with resting, RBF was not significantly changed immediately after continuous exercise (319 ± 102 vs. 308 ± 79 ml/min; p = 0.976) and exhibited no significant changes in the recovery phase. Moreover, urinary kidney injury molecule-1 (uKIM-1) level exhibited no significant change immediately after continuous exercise (0.52 ± 0.20 vs. 0.46 ± 0.27 μg/g creatinine; p = 0.447). In addition, the results revealed no significant change in urinary uKIM-1 in 60-min after exercise. Other renal injury biomarkers exhibited a similar pattern. These findings indicate that a single bout of moderate-intensity continuous exercise maintains RBF and does not induce renal injury.
由于运动减少了流向肾脏的血液，因此肾功能降低的个体应限制运动。目前尚未开发出针对肾功能降低个体的安全有效的运动方案。我们之前研究了运动强度与肾血流量（RBF）之间的关系，结果表明中等强度的运动不会降低 RBF。确定运动持续时间对 RBF 的影响可能具有重要的临床应用价值。本研究探讨了一次性连续运动至乳酸阈（LT）强度对肾血液动力学的影响。8 名成年男性参与了这项研究。参与者使用自行车测力计进行 30 分钟的 LT 强度有氧运动。在运动前、运动后和恢复期使用超声回波评估肾血液动力学。此外，在运动前、运动后和恢复期进行血液和尿液采样。与休息相比，连续运动后 RBF 没有明显变化（319±102 与 308±79 ml/min；p=0.976），在恢复期也没有明显变化。此外，连续运动后即刻尿肾损伤分子-1（uKIM-1）水平没有明显变化（0.52±0.20 与 0.46±0.27 μg/g 肌酐；p=0.447）。此外，运动后 60 分钟内尿 uKIM-1 也没有明显变化。其他肾损伤生物标志物也呈现出相似的模式。这些发现表明，一次性中等强度连续运动可维持 RBF 并不会引起肾损伤。
