Liampas Ioannis, Bourlios Stefanos, Siokas Vasileios, Aloizou Athina-Maria, Dervenis Panagiotis, Nasios Grigorios, Bakirtzis Christos, Bogdanos Dimitrios P, Dardiotis Efthimios
Department of Neurology, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, Larissa, Greece.
School of Medicine, University of Thessaly, Larissa, Greece.
Int J Neurosci. 2024 May;134(5):441-451. doi: 10.1080/00207454.2022.2110495. Epub 2022 Aug 9.
: Low serum vitamin D (VD) has been already associated with a series of highly prevalent pain-related conditions, including fibromyalgia, migraine and chronic widespread pain. Considering the potential interplay between VD and pain signalling pathways, the association of VD with tension-type headache (TTH) was reviewed. : A multifaceted narrative approach assessing the relationship of serum VD with TTH and TTH parameters, as well as the efficacy of VD supplementation for the prevention of TTH, was fostered. MEDLINE, CENTRAL and EMBASE were comprehensively searched for this purpose, while Google Scholar was also explored according to a structured approach. ClinicalTrials.gov and European Union Clinical Trials Register were explored for ongoing prevention trials. : Although available evidence was suggestive of an association between VD and TTH, mainly of the chronic type, the causal nature of the association remains to be determined. Considering the lack of longitudinal evidence, this relationship could arguably reflect behavioural patterns of headache sufferers. On the other hand, evidence principally originated from tertiary clinical settings (severe comorbidity burden) and researchers tend to report a concomitant association of both entities with generalized musculoskeletal compromise. In this context, the association between TTH and VD may represent nothing more than a secondary by-product of the simultaneous relationship of other comorbid diseases-conditions with both TTH and low serum VD. Regarding its efficacious properties, only one ongoing trial specifically designed to explore the efficacy of VD in chronic TTH in adults was retrieved. : There is no evidenced based indication for VD supplementation in TTH.
低血清维生素D（VD）已与一系列高度普遍的疼痛相关病症相关联，包括纤维肌痛、偏头痛和慢性广泛性疼痛。考虑到VD与疼痛信号通路之间的潜在相互作用，对VD与紧张型头痛（TTH）的关联进行了综述。：采用多方面的叙述方法来评估血清VD与TTH及TTH参数之间的关系，以及VD补充剂预防TTH的疗效。为此全面检索了MEDLINE、CENTRAL和EMBASE，同时还按照结构化方法搜索了谷歌学术。在ClinicalTrials.gov和欧盟临床试验注册库中搜索正在进行的预防试验。：尽管现有证据表明VD与TTH之间存在关联，主要是慢性TTH，但这种关联的因果性质仍有待确定。考虑到缺乏纵向证据，这种关系可以说是反映了头痛患者的行为模式。另一方面，证据主要来自三级临床环境（严重合并症负担），而且研究人员往往报告这两种情况都与全身性肌肉骨骼损伤同时存在关联。在这种情况下，TTH与VD之间的关联可能仅仅是其他合并疾病与TTH和低血清VD同时存在关系的一种次要副产品。关于其有效特性，仅检索到一项专门设计用于探索VD对成人慢性TTH疗效的正在进行的试验。：没有基于证据的迹象表明在TTH中补充VD有效。
