Zhang Xiaolei, Wu Jiangwen, Wu Ting, Guo Liwen, Zhang Ruiping, Jin Xin
Pain Department, Xiangyang No. 1 People's Hospital, Xiangyang City, China.
Food Nutr Res. 2024 Dec 9;68. doi: 10.29219/fnr.v68.10338. eCollection 2024.
This study was formulated with the objective of elucidating the correlation between 25-hydroxyvitamin D (25(OH)D) and the occurrence of severe headache or migraine, employing a cross-sectional analytical approach.
A cross-sectional survey was conducted over two cycles involving 7,661 participants, utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2004. A weighted logistic regression method was employed to construct a relationship model between the two variables. Subgroup analysis, adjusting for confounding factors, was performed through stratified analysis to explore the association between 25(OH)D and severe headaches or migraines. Finally, a restricted cubic spline regression (RCS) was utilized to investigate the non-linear relationship between the variables.
A total of 7,661 participants were included in this study, with an overall prevalence of severe headaches or migraines of 1,576/7,661 (22.3%). The results from all models consistently indicated a significant negative correlation between serum 25(OH)D levels and the risk of severe headaches or migraines ( < 0.05). Stratified analysis revealed that in the female population (odds ratios [OR]: 0.995, 95% CI: 0.991-0.998, = 0.001), never smokers (OR: 0.991, 95% CI: 0.985-0.997, = 0.003), and non-drinkers (OR: 0.993, 95% CI: 0.987-0.999, = 0.022), the risk of severe headaches or migraines decreased with increasing serum 25(OH)D concentrations. RCS results demonstrated a linear relationship between serum 25(OH)D levels and the risk of severe headaches or migraines.
We discovered a negative correlation between serum 25(OH)D levels and the prevalence of severe headaches or migraines, particularly in females, non-smokers, and non-hypertensive individuals. Further clinical research is necessary to confirm these findings, establish causality, and explore potential preventive and therapeutic mechanisms for migraines.
本研究旨在采用横断面分析方法，阐明25-羟基维生素D（25(OH)D）与严重头痛或偏头痛发生之间的相关性。
利用2001年至2004年期间进行的美国国家健康与营养检查调查（NHANES）的数据，对7661名参与者进行了两个周期的横断面调查。采用加权逻辑回归方法构建两个变量之间的关系模型。通过分层分析进行亚组分析，调整混杂因素，以探讨25(OH)D与严重头痛或偏头痛之间的关联。最后，利用受限立方样条回归（RCS）研究变量之间的非线性关系。
本研究共纳入7661名参与者，严重头痛或偏头痛的总体患病率为1576/7661（22.3%）。所有模型的结果均一致表明，血清25(OH)D水平与严重头痛或偏头痛的风险之间存在显著负相关（<0.05）。分层分析显示，在女性人群（优势比[OR]：0.995，95%置信区间：0.991-0.998，=0.001）、从不吸烟者（OR：0.991，95%置信区间：0.985-0.997，=0.003）和不饮酒者（OR：0.993，95%置信区间：0.987-0.999，=0.022）中，严重头痛或偏头痛的风险随着血清25(OH)D浓度的升高而降低。RCS结果表明血清25(OH)D水平与严重头痛或偏头痛的风险之间存在线性关系。
我们发现血清25(OH)D水平与严重头痛或偏头痛的患病率之间存在负相关，尤其是在女性、非吸烟者和非高血压个体中。需要进一步的临床研究来证实这些发现，确立因果关系，并探索偏头痛潜在的预防和治疗机制。
