Honig W J
Curr Med Res Opin. 1978;5(7):536-43. doi: 10.1185/03007997809108997.
A series of double-blind randomized trials was carried out in patients suffering from moderate to severe pain after meniscectomy to assess the analgesic effectiveness of diflunisal. In a single-dose study, 150 patients received either diflunisal (125 mg, 250 mg or 500 mg), aspirin (600 mg), or placebo, and hourly assessments were made of pain severity over an 8-hour period. The results showed that 500 mg diflunisal produced comparable relief to aspirin within 3 to 4 hours, but the analgesic effect continued for longer and was still very marked after 8 hours. A multi-dose study in 120 patients receiving doses of diflunisal (375 mg or 500 mg) or placebo confirmed the overall effectiveness of twice daily treatment with diflunisal. In a comparative study against oxyphenbutazone (200 mg t.i.d.), hourly pain scores made on the first post-operative day showed that a single dose of 500 mg diflunisal produced comparable relief over a 12-hour period to that with 2 doses of 200 mg oxyphenbutazone. Overall response to multiple doses was assessed as excellent or good by all the patients receiving diflunisal. Preliminary results are reported on the use of diflunisal in other painful conditions.
针对半月板切除术后中度至重度疼痛的患者开展了一系列双盲随机试验，以评估二氟尼柳的镇痛效果。在一项单剂量研究中，150名患者分别接受二氟尼柳（125毫克、250毫克或500毫克）、阿司匹林（600毫克）或安慰剂治疗，并在8小时内每小时评估一次疼痛严重程度。结果显示，500毫克二氟尼柳在3至4小时内产生的缓解效果与阿司匹林相当，但镇痛作用持续时间更长，8小时后仍非常显著。一项针对120名接受二氟尼柳（375毫克或500毫克）或安慰剂治疗的患者的多剂量研究证实了二氟尼柳每日两次治疗的总体有效性。在一项与羟苯丁宗（200毫克，每日三次）的对比研究中，术后第一天每小时的疼痛评分显示，单剂量500毫克二氟尼柳在12小时内产生的缓解效果与2剂200毫克羟苯丁宗相当。所有接受二氟尼柳治疗的患者对多剂量治疗的总体反应被评估为优秀或良好。报告了二氟尼柳在其他疼痛病症中的初步使用结果。
