Buck M E, Paintin D B
Curr Med Res Opin. 1978;5(7):548-9. doi: 10.1185/03007997809108999.
An on-going double-blind study was carried out in women requiring pain relief after episiotomy to compare the efficacy of 500 mg diflunisal twice daily, 65 mg dextropropoxyphene plus 650 mg paracetamol 3-times daily, and placebo. Fifty-seven patients, allocated at random to receive 2-days' treatment with one or other of the trial drugs, have been studied to date. The preliminary results, as assessed by descriptive rating scales, showed that all three treatments were equally effective in relieving spontaneous pain and pain at night. Patients' overall opinion showed no difference between treatments although the investigator assessed diflunisal to be better than the combined preparation and both to be better than placebo. A visual analogue scale of assessment is to be used for the remainder of the trial.
一项正在进行的双盲研究在需要缓解会阴切开术后疼痛的女性中开展,以比较每日两次服用500毫克二氟尼柳、每日三次服用65毫克右丙氧芬加650毫克对乙酰氨基酚以及安慰剂的疗效。截至目前,已有57名患者被随机分配接受其中一种试验药物为期2天的治疗并接受了研究。通过描述性评分量表评估的初步结果显示,所有三种治疗在缓解自发痛和夜间疼痛方面同样有效。患者的总体意见显示治疗之间没有差异,尽管研究者评估二氟尼柳比复方制剂更好,且二者均比安慰剂更好。试验的剩余部分将使用视觉模拟评分量表进行评估。