Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape, 5700, South Africa.
Department of Biotechnology & Food Technology, Faculty of Science, University of Johannesburg, Johannesburg, 2028, South Africa.
Ther Deliv. 2022 May;13(5):295-311. doi: 10.4155/tde-2021-0087. Epub 2022 Aug 4.
The current study is focused on the development of water-soluble wound dressings, which are potential dressings for the treatment of burn wounds. Sodium alginate-based dissolvable wound dressings were prepared and loaded with silver nanoparticles and various antibiotics (ampicillin and ciprofloxacin) followed by characterization and antibacterial studies. The prepared sodium alginate-based dissolvable wound dressing exhibited good porosity, water uptake and moisture content, promising antibacterial activity, high absorption capacity of simulated wound exudates, excellent water vapor transmission rate in the range of 2000 to 5000 g/m day, sustained drug-release profiles and water solubility. The wound dressings were active against and strains of bacteria. The results obtained revealed the wound dressing as potential wound dressings for burn wounds and sensitive skin.
本研究专注于水溶性伤口敷料的开发，此类敷料有望用于治疗烧伤创面。我们制备了基于海藻酸钠的可溶解伤口敷料，并负载了银纳米粒子和各种抗生素（氨苄西林和环丙沙星），随后对其进行了表征和抗菌研究。所制备的基于海藻酸钠的可溶解伤口敷料表现出良好的多孔性、吸水性和保水能力，具有良好的抗菌活性、对模拟伤口渗出液的高吸收能力、2000 至 5000g/m·day 范围内的水蒸气透过率高、药物释放曲线稳定和水溶性。该伤口敷料对 和 两种细菌均有抑制作用。研究结果表明，该伤口敷料有望成为治疗烧伤和敏感皮肤的新型伤口敷料。
