Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape, South Africa.
Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape, South Africa.
Int J Biol Macromol. 2021 Mar 1;172:350-359. doi: 10.1016/j.ijbiomac.2021.01.055. Epub 2021 Jan 13.
The improper management of wound exudates can expose the wound to bacterial invasion, skin maceration etc. thereby resulting in prolonged wound healing. Biopolymers are characterized by hydrophilic functional groups which when employed for the development of wound dressings promote the wound dressings capability to absorb a high amount of wound exudates. Alginate-gum acacia sponges were prepared from a combination of biopolymers such as sodium alginate and gum acacia in varying amounts with carbopol via crosslinking with 1 and 2% CaCl. The prepared sponges were loaded with a combination of ampicillin and norfloxacin. In vitro antibacterial analysis revealed that the antibacterial activity of the loaded antibiotics was retained and the sponges were effective against gram-positive and gram-negative bacteria. The sponges displayed rapid and high absorption capability in the range of 1022-2419% at pH 5.5 simulating wound exudates, and 2268-5042% at pH 7.4 simulating blood within a period of 1-3 h. Furthermore, the whole blood clotting studies further revealed low absorbance values when compared to the control revealing the good clotting capability of the sponges. The unique features of the sponges revealed their potential application for the management of infected, high exuding and bleeding wounds.
伤口渗液处理不当会使伤口暴露于细菌入侵、皮肤软化等情况，从而导致伤口愈合时间延长。生物聚合物的特点是具有亲水性官能团，将其用于开发伤口敷料时，可促进伤口敷料吸收大量伤口渗液的能力。海藻酸钠-阿拉伯树胶海绵由生物聚合物（如海藻酸钠和阿拉伯树胶）与卡波姆以 1%和 2%的 CaCl 交联，以不同比例组合而成。所制备的海绵负载氨苄青霉素和诺氟沙星的混合物。体外抗菌分析表明，负载抗生素的抗菌活性得以保留，并且这些海绵对革兰氏阳性菌和革兰氏阴性菌均有效。在 pH 5.5（模拟伤口渗液）时，这些海绵在 1-3 小时内显示出快速和高吸收能力，范围为 1022-2419%；在 pH 7.4（模拟血液）时，吸收能力为 2268-5042%。此外，全血凝固研究进一步表明，与对照相比，吸收值较低，表明海绵具有良好的凝血能力。这些海绵的独特特性表明它们有可能用于治疗感染、渗出量高和出血的伤口。
