Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation.
Klin Lab Diagn. 2022 Jul 18;67(7):399-406. doi: 10.51620/0869-2084-2022-67-7-399-406.
The aim of the study was to determine the main Candida species isolated from blood of cancer patients, to compare the taxonomic structure of strains obtained from children and adults with candidemia. In total, during the study period, candidemia was microbiologically proven by blood culture in 81 patients (duplicates were excluded). Patients in the intensive care unit (ICU) accounted for 35,8%. The total number of isolates elaborated was 82 strains of 10 Candida species. In general, in the taxonomic structure of candidemias, C. parapsilosis (61.0%) predominates, C. albicans (20.7%) is in the second place, followed by C. glabrata and C. lusitaniae (3.7% each); C. krusei, C. guilliermondii and C. tropicalis (2.4% each). C. parapsilosis was statistically significantly often isolated from blood compared to C. albicans (61.0% versus 20.7%, respectively, p<0.0001). Candidemia was statistically significantly more often detected in adults than in children (63.0% versus 37.0%, respectively, p<0.002). Moreover, in adults, C. parapsilosis was statistically significantly more often isolated from blood than C. albicans (70.6% versus 15.7%, respectively, p<0.0001). In children, there were no significant differences in the frequency of isolation of C. parapsilosis and C. albicans: the proportion of C. parapsilosis was 45.2%, C. albicans - 29.0%. Rare species were identified in 7.8% of cases in adults, and in 12.9% of cases in children without statistical difference (p>0.05). The proportion of Candida non-albicans during the study period was 79.3%, and C. parapsilosis is the main species in this group (76.9%).
本研究旨在确定从癌症患者血液中分离出的主要念珠菌种类，并比较从儿童和成人血液中分离出的菌株的分类结构。在研究期间，共有 81 名患者（排除重复）通过血液培养证实有菌血症。重症监护病房（ICU）的患者占 35.8%。共分离出 82 株 10 种念珠菌。总的来说，在菌血症的分类结构中，近平滑念珠菌（61.0%）占主导地位，白念珠菌（20.7%）次之，然后是光滑念珠菌和葡萄牙念珠菌（各占 3.7%）；克柔念珠菌、季也蒙念珠菌和热带念珠菌（各占 2.4%）。与白念珠菌相比，统计学上近平滑念珠菌从血液中分离的频率更高（分别为 61.0%和 20.7%，p<0.0001）。与儿童相比，统计学上成人的菌血症更为常见（分别为 63.0%和 37.0%，p<0.002）。此外，在成人中，统计学上从血液中分离出的近平滑念珠菌明显多于白念珠菌（分别为 70.6%和 15.7%，p<0.0001）。在儿童中，分离出的近平滑念珠菌和白念珠菌的频率无显著差异：近平滑念珠菌的比例为 45.2%，白念珠菌为 29.0%。在成人中，7.8%的病例和儿童中 12.9%的病例中鉴定出罕见菌种，但无统计学差异（p>0.05）。在研究期间，非白念珠菌的比例为 79.3%，其中近平滑念珠菌是该组的主要菌种（76.9%）。
