Mazeron J J, Crook J, Mahot P, Martin M, Raynal M, Faraldi M, Juvanon J M, Peynègre R, Pierquin B
Ann Otolaryngol Chir Cervicofac. 1987;104(3):197-203.
From April 1971 to October 1984, 71 patients with T1 or T2 tumors of the faucial arch were treated according to the following protocol: Telecobalt therapy to the primary site and to the neck nodes to a dose of 45 Gy. Brachytherapy to the primary site to a dose of 25 to 30 Gy using iridium 192. For node positive patients, boost dose to involved neck nodes with electrons, or radical neck dissection. Seven patients with T1N0 tumors were treated exclusively by 60 Gy iridium implantation. The crude disease free survival is 66% for the group of patients with tumors of the tonsillar region and 41% for those with tumors of the soft palate or uvula. Local control of tonsillar tumors was 98% while that of tumors of the soft palate was 85%. Regional control was 98% for the N0 group and 87% for the N1-3 group. Five cases of soft tissue ulceration were observed, all of which healed spontaneously within a few months. Less salivary impairment was seen than after treatment by external irradiation alone. While these promising results have encouraged the use of this protocol, the introduction of the plastic tube technique has expanded the indications to include almost all T1 and T2 tumors of the faucial arch without obvious extension to the base of tongue or retromolar trigone.
1971年4月至1984年10月，71例患有腭弓T1或T2期肿瘤的患者按照以下方案接受治疗：对原发部位和颈部淋巴结进行远距离钴治疗，剂量为45 Gy。使用铱192对原发部位进行近距离放疗，剂量为25至30 Gy。对于淋巴结阳性患者，用电子线对受累颈部淋巴结进行加量照射，或进行根治性颈清扫术。7例T1N0期肿瘤患者仅接受了60 Gy的铱植入治疗。扁桃体区肿瘤患者组的粗无病生存率为66%，软腭或悬雍垂肿瘤患者组为41%。扁桃体肿瘤的局部控制率为98%，而软腭肿瘤为85%。N0组的区域控制率为98%，N1 - 3组为87%。观察到5例软组织溃疡，所有病例均在数月内自发愈合。与单纯外照射治疗相比，唾液腺损伤较轻。虽然这些有前景的结果鼓励了该方案的使用，但塑料导管技术的引入扩大了适应症，几乎涵盖了所有腭弓T1和T2期肿瘤，且无明显向舌根或磨牙后三角区扩展。
