肥胖对尼日利亚-非洲正常、准肥胖和肥胖人群抵抗素浓度的影响。

Effect of Obesity on Resistin Concentrations in Normal, Pre-Obese and Obese Apparently Healthy Nigerian-Africans.

机构信息

Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Kaduna State, Nigeria.

Department of Medicine, Niger Delta University Teaching Hospital, Okolobiri, Bayelsa State, Nigeria.

出版信息

West Afr J Med. 2022 Jul 31;39(7):791-702.

DOI:

PMID:35924881

Abstract

BACKGROUND: Among Caucasians, conflicting findings exist on resistin in obesity and its relation to metabolic indices, with scarcity of such in Nigerian-Africans. Therefore, the study assessed plasma resistin and explored its relationship with obesity and selected cardiometabolic risks. METHODS: A cross-sectional comparative-analytical study on 87 randomly-selected non-diabetic Nigerians allocated into three groups by the WHO criteria: 24 normal; 23 pre-obese and 40 obese. Resistin was measured via enzyme-linked immunosorbent assay. One-way Analysis of Variance (ANOVA) and Independent Kruskal-Wallis test determined differences in BMI categories. Spearman's correlation and Multivariate Logistic Regression assessed relationships. A sub-group analysis excluding subjects with first time incidental finding of high blood pressure, determined further associations. RESULTS: Resistin concentrations trended towards higher levels in obese than normal controls {Mean ± SD, 6.72 ± 4.25 ng/mL versus 5.10 ± 2.58 ng/mL}, with significantly (p<0.05) higher obesity indices, fasting insulin (FI) and HOMA-IR in obese than normal controls. Hyperresistinaemia involved 8(9.2%) subjects as against 79(90.8%) with normoresistinaemia, {Mean ± SD, 15.1 ± 2.6 ng/mL versus 5.3 ± 2.8 ng/mL, (p<0.001)}. Log (Ln10) hyperresistinaemia was significantly (p<0.05) positively correlated to obesity indices (BMI, r=0.29, p=0.006; WC, r=0.23, p=0.04) but not to HOMA-IR, FI, FBG, SBP, DBP and age. Ln10 Hyperresistinaemia in females was significantly (p=0.05, OR: 1.12, 95% CI, 1.0-1.25) associated with central obesity by the IDF criteria in both unadjusted and step-wise age, sex, SBP & DBP adjusted models. Similar finding was for generalized obesity, albeit with low odds in all subjects (p=0.009), with persistence in the step-wise age, sex and SBP/DBP adjusted models. In the sub-group analysis, resistin showed similar findings to that of the whole sample population. CONCLUSION: Resistin concentrations trended towards higher levels in obese than normal healthy non-diabetic Nigerian-Africans. Its lack of correlation with HOMA-IR and mild correlations/marginal relations to obesity indices may suggest possible interplay of other proinflammatory cytokines or hormones which may be evaluated in further studies.

摘要

背景：在白种人中，关于抵抗素在肥胖症中的作用及其与代谢指标的关系存在相互矛盾的发现，而在尼日利亚-非洲人中，这种情况则很少见。因此，本研究评估了血浆抵抗素，并探讨了其与肥胖症和某些心血管代谢风险的关系。

方法：这是一项横断面比较分析研究，共纳入 87 名随机选择的非糖尿病尼日利亚人，根据世界卫生组织的标准分为三组：24 名正常体重者、23 名准肥胖者和 40 名肥胖者。通过酶联免疫吸附试验测量抵抗素。采用单因素方差分析（ANOVA）和独立 Kruskal-Wallis 检验来确定 BMI 类别之间的差异。Spearman 相关分析和多变量逻辑回归分析评估了相关性。排除首次发现高血压的患者的亚组分析进一步确定了相关性。

结果：与正常对照组相比，肥胖组的抵抗素浓度呈上升趋势{平均值 ± 标准差，6.72 ± 4.25 ng/mL 与 5.10 ± 2.58 ng/mL}，且肥胖指数、空腹胰岛素（FI）和 HOMA-IR 均显著升高（p<0.05）。高抵抗素血症患者占 8（9.2%），而正常抵抗素血症患者占 79（90.8%）{平均值 ± 标准差，15.1 ± 2.6 ng/mL 与 5.3 ± 2.8 ng/mL，（p<0.001）}。Log（Ln10）高抵抗素血症与肥胖指数（BMI，r=0.29，p=0.006；WC，r=0.23，p=0.04）呈显著正相关，但与 HOMA-IR、FI、FBG、SBP、DBP 和年龄无显著相关性。女性的 Ln10 高抵抗素血症与 IDF 标准下的中心性肥胖显著相关（p=0.05，OR：1.12，95%CI，1.0-1.25），无论在未调整还是逐步调整年龄、性别、SBP 和 DBP 后，均具有统计学意义。全身性肥胖也存在类似的发现，但在所有受试者中的比值较低（p=0.009），且在逐步调整年龄、性别和 SBP/DBP 后仍具有统计学意义。在亚组分析中，抵抗素的发现与整个样本人群相似。

结论：与健康的非糖尿病尼日利亚-非洲人相比，肥胖者的抵抗素浓度呈上升趋势。抵抗素与 HOMA-IR 缺乏相关性，与肥胖指数呈轻度相关性或边缘相关性，这可能提示可能存在其他促炎细胞因子或激素的相互作用，这可以在进一步的研究中进行评估。