Ghrelin、 resistin 和胰岛素在苏丹瓦德迈达尼肥胖糖尿病女性中的作用。

Ghrelin, resistin and insulin in obese diabetic women in Wad-Madani, Sudan.

机构信息

Department of Medical Physiology, Faculty of Medicine, King Faisal University, Alahsa, Saudi Arabia.

Department of Physiology, Nile College, Khartoum, Sudan.

出版信息

Afr Health Sci. 2020 Mar;20(1):266-276. doi: 10.4314/ahs.v20i1.32.

DOI:10.4314/ahs.v20i1.32

PMID:33402915

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7750074/

Abstract

BACKGROUND

Obesity in the Sudan is increasing at alarming rate with the tendency of reaching an epidemic proportion in women. It is commonly associated with type 2 diabetes (T2D). Some adipokine hormones such as resistin are associated with obesity.

OBJECTIVES

To study how the levels of resistin, ghrelin and insulin are associated with obesity,fat distribution and (T2D) and to ascertain any interrelationships between them.

SUBJECTS AND METHODS

150 women, age ≥18 years old, resident in Wad-Madani town, Sudan were participated in the study. They were divided into 3 groups according to body mass index (BMI) value: I (normal weight), II (overweight) and III (obese diabetic). Fasting serum resistin and ghrelin concentrations were measured using ELISA method. Insulin levels were determined by radioimmunoassay(RIA).

RESULTS

The mean±SD levels of resistin 5.80±4.91ng/mL,Ghrelin107.60±26.67pg/M and Insulin 11.92±8.54mLU/ml in obese diabetic were found to be greater than in normal or overweight women. In normal weight values were 3.07±2.15 ng/mL 83.30±13.38pg/mL, and 6.62±6.77mLU/ml for resistini, ghrelin and Insulin, respectively. Values for overweight women 3.64±2.63 pg/mL 90±17.35 pg/mL and 8.13±7.54 mLU/ml for resistin, ghrelin and insulin respectively.

CONCLUSIONS AND RECOMMENDATIONS

Increased BMI, waist circumference (WC) and hormones (ghrelin and resistin) were associated with insulin resistance. Further studies are needed to accept or refute these findings.

摘要

背景

苏丹的肥胖率正在以惊人的速度增长，女性肥胖有达到流行程度的趋势。它通常与 2 型糖尿病（T2D）有关。一些脂肪细胞因子，如抵抗素，与肥胖有关。

目的

研究抵抗素、胃饥饿素和胰岛素的水平与肥胖、脂肪分布和（T2D）的关系，并确定它们之间的任何相互关系。

受试者和方法

150 名年龄≥18 岁的女性居住在苏丹瓦德-马丹镇，参与了这项研究。根据体重指数（BMI）值将她们分为 3 组：I（正常体重）、II（超重）和 III（肥胖糖尿病）。使用 ELISA 法测量空腹血清抵抗素和胃饥饿素浓度。胰岛素水平通过放射免疫测定（RIA）确定。

结果

肥胖糖尿病组的抵抗素 5.80±4.91ng/mL、Ghrelin107.60±26.67pg/M 和胰岛素 11.92±8.54mLU/ml 的平均±SD 值高于正常或超重女性。在正常体重值中，抵抗素、胃饥饿素和胰岛素分别为 3.07±2.15ng/mL、83.30±13.38pg/mL 和 6.62±6.77mLU/ml。超重女性的数值分别为 3.64±2.63pg/mL、90±17.35pg/mL 和 8.13±7.54mLU/ml。