Leptin Concentrations in Non-Obese and Obese Non-Diabetes Nigerian-Africans.

BACKGROUND

Controversial findings exist on the role of leptin in obesity and its correlation with metabolic variables, with few data emanating from Nigerian-Africans. Plasma leptin was therefore determined in obese and non-obese. Its relationship with obesity indices and metabolic variables were further envisaged.

MATERIALS AND METHODS

A cross-sectional comparative study on 87 randomly-selected non-diabetes Nigerians distributed into 3 groups (24 normal, 23 pre-obese and 40 obese). Obesity indices, fasting Insulin (FI) and homeostasis model assessment-insulin resistance (HOMA-IR) were determined. Plasma leptin was determined by sandwich enzyme-linked immunosorbent assay. Mann-Whitney -test, Independent Kruskal-Wallis test, Spearman correlation and Step-wise Multivariate Logistic Regression analysis determined outcomes.

RESULTS

Median+IQR leptin concentrations were higher in obese {61.8(40.8, 91.4) ng/mL, } than pre-obese {42.7(28.0, 51.7) ng/mL, } and normal {28.6(20.7, 39.8) ng/mL, } BMI categories. Leptin was higher () in females than males {Median+IQR, 52.0 (35.0, 80.0) ng/mL versus 34.0(24, 65.0 ng/mL)}. Leptin was positively correlated with body fat percentage (BFP), r=0.57; waist circumference (WC), r=0.46 and body mass index (BMI), r=0.50, , respectively in all subjects, with higher correlation coefficient in males than females. Leptin showed sex-specific correlations to age, FI and HOMA-IR. In the unadjusted models, central obesity/generalized obesity, WC, BMI, BFP, combined pre-obesity/obesity, younger age and female sex were significantly () associated with log-transformed leptin. WC (OR: 1.2, 95% CI, 1.05-1.38, ), BFP (OR: 1.41, 95% CI, 1.07-1.84, ) and BMI (OR: 1.6, 95% CI, 1.13-2.31, ) in men and all subjects, were independently associated with hyperleptinaemia following adjustments.

CONCLUSION

Plasma leptin concentrations, fasting insulin and insulin resistance are higher in obese and pre-obese than normal controls, with females showing higher leptin concentrations than males. Leptin is independently related to BMI, BFP, WC, female sex and generalized/central obesity in Nigerian-Africans especially males. It showed sex-specific relations to age, fasting insulin and HOMA-IR.