Reproductive Medical Center, Henan Province Key Laboratory for Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, 1# Jianshe East, Zhengzhou, Henan Province, China.
J Assist Reprod Genet. 2022 Sep;39(9):2019-2026. doi: 10.1007/s10815-022-02563-4. Epub 2022 Aug 4.
To compare ovarian response and the number of transferable embryos between women with balanced autosomal translocations and women whose partners carry the translocation (control group). To investigate the predictive value of metaphase II (MII) oocyte number and biopsied embryo number for gaining at lowest one transferable embryo.
We retrospectively analyzed 1942 preimplantation genetic testing for structural rearrangements (PGT-SR) cycles of 1505 balanced autosomal translocation couples over 8 years. All cycles were divided into two subgroups: Robertsonian and reciprocal translocations (ROBT and ReBT). Receiver operator characteristic (ROC) curves were plotted to ascertain a cutoff of MII oocytes and biopsied embryos as predictors of gaining at lowest one transferable embryo.
There were no statistical differences in baseline features or ovarian response indicators regarding the number of retrieved/MII oocytes, E2 level on the day of HCG, and ovarian sensitivity index (OSI) between women with balanced autosomal translocations and control group (P > 0.05). A decreased number of transferable embryos were found in women with balanced autosomal translocations regardless of the type of translocation. The cutoff values for gaining at lowest one transferable embryo are 12.5 MII oocytes and 4.5 biopsied embryos, respectively.
Women with balanced autosomal translocations have a normal ovarian response, but fewer transferable embryos, meaning that higher gonadotropin (Gn) doses may be required to increase transferable embryos. When fewer than 12.5 MII oocytes or 4.5 blastocysts are obtained in a PGT-SR cycle, couples should be notified that the likelihood of gaining a transferable embryo is low.
比较平衡染色体易位妇女与配偶携带易位的妇女（对照组）之间的卵巢反应和可移植胚胎数量。探讨中期 II（MII）卵母细胞数量和活检胚胎数量对获得至少一个可移植胚胎的预测价值。
我们回顾性分析了 8 年来 1505 对平衡常染色体易位夫妇的 1942 个胚胎植入前遗传学检测结构重排（PGT-SR）周期。所有周期均分为两个亚组：罗氏易位和相互易位（ROBT 和 ReBT）。绘制受试者工作特征（ROC）曲线，以确定 MII 卵母细胞和活检胚胎的截断值作为获得至少一个可移植胚胎的预测因子。
在基础特征或卵巢反应指标方面，包括获卵数/ MII 卵母细胞数、HCG 日 E2 水平和卵巢敏感指数（OSI），平衡易位组与对照组之间无统计学差异（P>0.05）。无论易位类型如何，平衡易位妇女的可移植胚胎数量均减少。获得至少一个可移植胚胎的截断值分别为 12.5 个 MII 卵母细胞和 4.5 个活检胚胎。
平衡常染色体易位妇女的卵巢反应正常，但可移植胚胎较少，这意味着需要更高剂量的促性腺激素（Gn）来增加可移植胚胎。当 PGT-SR 周期中获得的 MII 卵母细胞少于 12.5 个或活检胚胎少于 4.5 个时，应告知夫妇获得可移植胚胎的可能性较低。
