Department of General Surgery, Shaare Zedek Medical Centre, The Hebrew University School of Medicine, Jerusalem, Israel.
Department of General Surgery, Shaare Zedek Medical Centre, The Hebrew University School of Medicine, Jerusalem, Israel.
J Surg Res. 2022 Nov;279:633-638. doi: 10.1016/j.jss.2022.06.040. Epub 2022 Jun 27.
The relationship that vaccination against corona virus disease 19 (COVID-19) or recovery from the acute form of the illness may have with the incidence or severity of acute appendicitis (AA) has not been explored. The aim of this study was to evaluate this relationship.
A single centre retrospective study of all consecutive adult patients presenting with AA in the 6 mo after the initiation of a national vaccination program was performed. The presenting characteristics and pathological data of patients who had either been vaccinated against or recovered from COVID-19 were compared with those who had not. In addition, historical data from the equivalent period 12 and 24 mo beforehand was also extracted. The incidence of AA was compared between each of these time-frames.
Of the 258 patients initially identified, 255 were included in the analysis of which 156 had either been vaccinated and/or recovered from COVID-19 (61.2%) whilst 99 (38.8%) patients had not. When comparing these two groups, there were no significant differences in the presenting characteristics, operative findings or postoperative courses. There was also no significant change in the incidence of AA when comparing the study dates with historical data (median weekly incidence of AA 8.0 versus 8.0 versus 8.0 respectively, P = 0.672).
Based on the data presented here, we failed to find a relationship between a national vaccination program and both the nature and incidence of AA presenting to a busy urban hospital.
接种新冠病毒病 19 型（COVID-19）疫苗或从急性疾病中康复，与急性阑尾炎（AA）的发病或严重程度之间的关系尚未得到探索。本研究旨在评估这种关系。
对在全国疫苗接种计划开始后 6 个月内连续出现 AA 的所有成年患者进行了单中心回顾性研究。比较了接种过 COVID-19 疫苗或从 COVID-19 中康复的患者与未接种或未康复的患者的临床表现和病理数据。此外，还提取了 12 个月和 24 个月前的同期历史数据。比较了这些时间段之间 AA 的发病率。
在最初确定的 258 名患者中，有 255 名患者纳入了分析，其中 156 名患者接种了疫苗并/或从 COVID-19 中康复（61.2%），而 99 名患者未接种疫苗（38.8%）。比较这两组时，在临床表现、手术发现或术后过程方面均无显著差异。与历史数据相比，在比较研究日期时，AA 的发病率也没有显著变化（每周 AA 的中位数发病率分别为 8.0 比 8.0 比 8.0，P=0.672）。
根据本研究提供的数据，我们未能发现全国性疫苗接种计划与繁忙城市医院就诊的 AA 的性质和发病率之间存在关系。
