Bégin M E, Ells G
Anticancer Res. 1987 Mar-Apr;7(2):215-7.
The relative cytotoxic potential of C18 carbon fatty acids on human breast tumor cells was determined. The saturated (18:0) and monounsaturated (cis C18:1n-9) fatty acids exhibited no cytotoxic effects, while cis polyunsaturated fatty acids (C18:2n-6, C18:3n-6, C18:3n-3, C20:4n-6, C20:5n-3 and C22:6n-3) were cytotoxic dose-dependently. Fatty acids with 3, 4 and 5 double bonds were more effective than those with 2 and 6 double bonds. Cis, but not trans, isomers of C18:2n-6 were cytotoxic. The cells did not demonstrate resistance to the cytotoxic effects induced by the fatty acids at any concentrations. It is concluded that in these cells the cytotoxic potential of the fatty acids depended on the number, the position and the geometric form of the double bond in the fatty acid carbon chain.
测定了C18碳脂肪酸对人乳腺肿瘤细胞的相对细胞毒性潜力。饱和脂肪酸（18:0）和单不饱和脂肪酸（顺式C18:1n-9）未表现出细胞毒性作用，而顺式多不饱和脂肪酸（C18:2n-6、C18:3n-6、C18:3n-3、C20:4n-6、C20:5n-3和C22:6n-3）呈剂量依赖性细胞毒性。具有3、4和5个双键的脂肪酸比具有2和6个双键的脂肪酸更有效。C18:2n-6的顺式异构体（而非反式异构体）具有细胞毒性。在任何浓度下，细胞均未表现出对脂肪酸诱导的细胞毒性作用的抗性。得出的结论是，在这些细胞中，脂肪酸的细胞毒性潜力取决于脂肪酸碳链中双键的数量、位置和几何形式。
