School of Biomedical Engineering, Southern Medical University, Guangdong 510515, China; and Guangzhou Key Laboratory of Medical Radiation Imaging and Detection Technology, Southern Medical University, Guangdong 510515, People's Republic of China.
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangdong 510515, People's Republic of China.
Phys Med Biol. 2022 Sep 7;67(18). doi: 10.1088/1361-6560/ac8717.
Computed tomography perfusion (CTP) is a functional imaging that allows for providing capillary-level hemodynamics information of the desired tissue in clinics. In this paper, we aim to offer insight into CTP imaging which covers the basics and current state of CTP imaging, then summarize the technical applications in the CTP imaging as well as the future technological potential. At first, we focus on the fundamentals of CTP imaging including systematically summarized CTP image acquisition and hemodynamic parameter map estimation techniques. A short assessment is presented to outline the clinical applications with CTP imaging, and then a review of radiation dose effect of the CTP imaging on the different applications is presented. We present a categorized methodology review on known and potential solvable challenges of radiation dose reduction in CTP imaging. To evaluate the quality of CTP images, we list various standardized performance metrics. Moreover, we present a review on the determination of infarct and penumbra. Finally, we reveal the popularity and future trend of CTP imaging.
计算机断层灌注成像（CTP）是一种功能成像，可以在临床中提供所需组织的毛细血管水平血流动力学信息。本文旨在深入了解 CTP 成像，涵盖 CTP 成像的基础知识和现状，然后总结 CTP 成像中的技术应用以及未来的技术潜力。首先，我们专注于 CTP 成像的基础，包括系统地总结了 CTP 图像采集和血流动力学参数图估计技术。我们对 CTP 成像的临床应用进行了简短的评估，然后对 CTP 成像在不同应用中的辐射剂量效应进行了综述。我们对 CTP 成像中已知和潜在可解决的降低辐射剂量的挑战进行了分类方法学综述。为了评估 CTP 图像的质量，我们列出了各种标准化性能指标。此外，我们对梗死和半影区的确定进行了综述。最后，我们揭示了 CTP 成像的普及程度和未来趋势。
