严重急性呼吸综合征冠状病毒 2 感染孕妇的早产。
Preterm birth among pregnant persons with severe acute respiratory syndrome Coronavirus 2 infection.
机构信息
Centers for Disease Control and Prevention COVID-19 Response, Epidemiology Task Force, Atlanta, GA, USA.
Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, Atlanta, GA, USA.
出版信息
J Perinatol. 2022 Oct;42(10):1328-1337. doi: 10.1038/s41372-022-01467-6. Epub 2022 Aug 4.
OBJECTIVE
We examined the relationship between trimester of SARS-CoV-2 infection, illness severity, and risk for preterm birth.
STUDY DESIGN
We analyzed data for 6336 pregnant persons with SARS-CoV-2 infection in 2020 in the United States. Risk ratios for preterm birth were calculated for illness severity, trimester of infection, and illness severity stratified by trimester of infection adjusted for age, selected underlying medical conditions, and pregnancy complications.
RESULT
Pregnant persons with critical COVID-19 or asymptomatic infection, compared to mild COVID-19, in the second or third trimester were at increased risk of preterm birth. Pregnant persons with moderate-to-severe COVID-19 did not show increased risk of preterm birth in any trimester.
CONCLUSION
Critical COVID-19 in the second or third trimester was associated with increased risk of preterm birth. This finding can be used to guide prevention strategies, including vaccination, and inform clinical practices for pregnant persons.
目的
我们研究了 SARS-CoV-2 感染的孕期、疾病严重程度与早产风险之间的关系。
研究设计
我们分析了 2020 年美国 6336 名 SARS-CoV-2 感染孕妇的数据。根据疾病严重程度、感染孕期以及感染孕期分层的疾病严重程度，计算了早产风险比，并进行了年龄、选定的基础疾病和妊娠并发症的调整。
结果
与轻症 COVID-19 相比，重症 COVID-19 或无症状感染孕妇在第二或第三孕期发生早产的风险增加。任何孕期患有中重度 COVID-19 的孕妇早产风险均无增加。
结论
第二或第三孕期的重症 COVID-19 与早产风险增加相关。这一发现可用于指导预防策略，包括疫苗接种，并为孕妇的临床实践提供信息。
Zotero 插件