REACH: The Centre for Research in Ageing and Cognitive Health, University of Exeter Medical School and College of Life and Environmental Sciences, St Luke's Campus, Exeter, UK.
King's College London, Social Epidemiology Research Group, Health Service and Population Research, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Age Ageing. 2019 May 1;48(3):361-367. doi: 10.1093/ageing/afy155.
The aim was to investigate the co-morbidity profile of people with dementia and examine the associations between severity of co-morbidity, health-related quality of life (HRQoL) and quality of life (QoL).
The improving the experience of Dementia and Enhancing Active Life (IDEAL) cohort consisted of 1,547 people diagnosed with dementia who provided information on the number and type of co-morbid conditions. Participants also provided ratings of their health-related and dementia-specific QoL.
The majority of the sample were living with more than one chronic condition. Hypertension was commonly reported and frequently combined with connective tissue disease, diabetes and depression. The number of co-morbid conditions was associated with low QoL scores, and those with severe co-morbidity (≥5 conditions) showed the greatest impact on their well-being.
Co-morbidity is an important risk factor for poor QoL and health status in people with dementia. Greater recognition of the nature and impact of co-morbidity is needed to inform support and interventions for people with dementia and a multidisciplinary approach to care provision is recommended.
本研究旨在调查痴呆患者的合并症特征，并探讨合并症严重程度与健康相关生活质量（HRQoL）和生活质量（QoL）之间的关系。
改善痴呆患者体验和增强其活力（IDEAL）队列纳入了 1547 名确诊痴呆的患者，他们提供了合并症的数量和类型信息。参与者还对其与痴呆相关的健康和特定于痴呆的生活质量进行了评分。
大多数样本患有多种慢性疾病。高血压很常见，常与结缔组织疾病、糖尿病和抑郁症合并出现。合并症的数量与 QoL 评分较低有关，合并症严重（≥5 种）的患者对其幸福感影响最大。
合并症是痴呆患者生活质量和健康状况较差的一个重要危险因素。需要更深入地了解合并症的性质和影响，以为痴呆患者提供支持和干预措施，并建议采用多学科的护理提供方法。
