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[具体草药名称1]、[具体草药名称2]和[具体草药名称3]的草药组合调节2型固有淋巴细胞和巨噬细胞的功能，有助于胶原诱导性关节炎的消退。

The Herbal Combination of , , and Regulates the Functions of Type 2 Innate Lymphocytes and Macrophages Contributing to the Resolution of Collagen-Induced Arthritis.

作者信息

Feng Guiyu, Li Dongyang, Liu Juan, Sun Song, Zhang Pingxin, Liu Wei, Zhang Yingkai, Meng Boyang, Li Jinyu, Chai Limin

机构信息

Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.

Department of Pharmacy, The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China.

出版信息

Front Pharmacol. 2022 Jul 19;13:964559. doi: 10.3389/fphar.2022.964559. eCollection 2022.

DOI:10.3389/fphar.2022.964559
PMID:35928276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9343953/
Abstract

Type 2 innate lymphocytes (ILC2s), promoting inflammation resolution, was a potential target for rheumatoid arthritis (RA) treatment. Our previous studies confirmed that . and . could intervene in immunologic balance of T lymphocytes. . also have anti-inflammatory therapeutic effects. In this study, the possible molecular mechanisms of the combination of these three herbs for the functions of ILC2s and macrophages contributing to the resolution of collagen-induced arthritis (CIA) were studied. Therefore, we used . , . , and . as treatment. The synovial inflammation and articular cartilage destruction were alleviated after herbal treatment. The percentages of ILC2s and Tregs increased significantly. The differentiation of Th17 cells and the secretion of IL-17 and IFN-γ significantly decreased. In addition, treatment by the combination of these three herbs could increase the level of anti-inflammatory cytokine IL-4 secreted, active the STAT6 signaling pathway, and then contribute to the transformation of M1 macrophages to M2 phenotype. The combination of the three herbs could promote inflammation resolution of synovial tissue by regulating ILC2s immune response network. The synergistic effects of three drugs were superior to the combination of . and . or . alone.

摘要

2型固有淋巴细胞（ILC2s）可促进炎症消退，是类风湿性关节炎（RA）治疗的潜在靶点。我们之前的研究证实，……和……可干预T淋巴细胞的免疫平衡。……也具有抗炎治疗作用。在本研究中，研究了这三种草药联合作用于ILC2s和巨噬细胞功能以促进胶原诱导性关节炎（CIA）消退的可能分子机制。因此，我们使用……、……和……进行治疗。草药治疗后，滑膜炎症和关节软骨破坏得到缓解。ILC2s和调节性T细胞（Tregs）的百分比显著增加。Th17细胞的分化以及白细胞介素-17（IL-17）和干扰素-γ（IFN-γ）的分泌显著减少。此外，这三种草药联合治疗可增加抗炎细胞因子IL-4的分泌水平，激活信号转导和转录激活因子6（STAT6）信号通路，进而促进M1巨噬细胞向M2表型转化。这三种草药联合使用可通过调节ILC2s免疫反应网络促进滑膜组织炎症消退。三种药物的协同作用优于……和……联合或单独使用……。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/d1e3993b7bec/fphar-13-964559-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/95b8b0e2e8a6/fphar-13-964559-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/deaa822a0ad1/fphar-13-964559-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/dd8dcd3ea4e7/fphar-13-964559-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/6f2a39c33e8f/fphar-13-964559-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/bd3bf403246a/fphar-13-964559-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/0344a44ab34b/fphar-13-964559-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/cc7a712af196/fphar-13-964559-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/94704b18a099/fphar-13-964559-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/d1e3993b7bec/fphar-13-964559-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/95b8b0e2e8a6/fphar-13-964559-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/deaa822a0ad1/fphar-13-964559-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/dd8dcd3ea4e7/fphar-13-964559-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/6f2a39c33e8f/fphar-13-964559-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/bd3bf403246a/fphar-13-964559-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/0344a44ab34b/fphar-13-964559-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/cc7a712af196/fphar-13-964559-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/94704b18a099/fphar-13-964559-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785c/9343953/d1e3993b7bec/fphar-13-964559-g009.jpg

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