RoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania.
Department of Neurosciences, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
J Med Life. 2022 Jun;15(6):860-866. doi: 10.25122/jml-2022-0156.
Paraneoplastic cerebellar ataxia is a paraneoplastic neurological syndrome (PNS) that can be the first clinical manifestation of underlying cancer. It is usually associated with onco-neuronal antibodies and has no other specific paraclinical feature. After the surgical and oncologic treatment of the primary cancer, the remaining neurological symptoms have limited therapeutic options. We describe a case of severe ataxia as the primary manifestation of ovarian cancer, with a significant clinical and paraclinical improvement of the neurological symptoms after 20 sessions of rTMS intervention.
副肿瘤性小脑共济失调是一种副肿瘤性神经综合征(PNS),可作为潜在癌症的首发临床表现。它通常与肿瘤神经抗体相关,没有其他特定的临床特征。在原发性癌症的手术和肿瘤治疗后,剩余的神经症状治疗选择有限。我们描述了一例以严重共济失调为首发表现的卵巢癌病例,在接受 20 次 rTMS 干预后,神经症状有显著的临床和临床改善。