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副肿瘤性小脑性共济失调及副肿瘤综合征

Paraneoplastic cerebellar ataxia and the paraneoplastic syndromes.

作者信息

Afzal Sadaf, Recio Maria, Shamim Sadat

机构信息

Division of Neurology, Department of Internal Medicine, Baylor University Medical Center at Dallas.

出版信息

Proc (Bayl Univ Med Cent). 2015 Apr;28(2):217-20. doi: 10.1080/08998280.2015.11929234.

Abstract

Paraneoplastic cerebellar ataxia, also known as paraneoplastic cerebellar degeneration, is one of the wide array of paraneoplastic neurological syndromes in which neurological symptoms are indirectly caused by an underlying malignancy, most commonly gynecological, breast, or lung cancer or Hodgkin's lymphoma. We describe a patient with severe cerebellar dysfunction attributed to a paraneoplastic neurological syndrome. The case highlights the need to look for paraneoplastic syndromes-both to discover malignancies early, at a treatable stage, and, as in our case, to address very distressing symptoms for the patient's relief even if the malignancy is not curable.

摘要

副肿瘤性小脑共济失调,也称为副肿瘤性小脑变性,是众多副肿瘤性神经综合征之一,其中神经症状由潜在恶性肿瘤间接引起,最常见的是妇科、乳腺癌或肺癌或霍奇金淋巴瘤。我们描述了一名因副肿瘤性神经综合征导致严重小脑功能障碍的患者。该病例强调了寻找副肿瘤综合征的必要性——既能在可治疗阶段早期发现恶性肿瘤,又能像我们的病例一样,即使恶性肿瘤无法治愈,也能缓解患者非常痛苦的症状。

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