Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
School of Dentistry, University of Sheffield, Sheffield, UK.
Reprod Fertil. 2022 Jul 18;3(3):L6-L8. doi: 10.1530/RAF-22-0026. eCollection 2022 Jul 1.
The need to develop new treatments to prevent unprompted premature delivery before 37 weeks of pregnancy remains pressing and unmet. Bacteria ( species) that promote vaginal health produce biochemical compounds that prevent the growth of microbes such as . Overgrowth of can cause vaginal infection with smelly discharge and increase a woman's risk of sexually transmitted infections and premature delivery. In this study, we examined how normal health-promoting () and potentially harmful () vaginal bacteria interact in a laboratory setting. This was in order to observe natural and effective agent(s) from that can hinder the growth of and accompanying immune response. We observed that clears by itself and with several biochemical compounds that it produces. Such biochemical compounds can be developed into treatment for vaginal infections and premature delivery due to infection and inappropriate immune response.
开发新的治疗方法以预防怀孕 37 周前未经提示的早产仍然是紧迫且未得到满足的需求。促进阴道健康的细菌（物种）会产生生化化合物，以阻止微生物如 的生长。的过度生长会导致阴道感染，伴有恶臭分泌物，并增加女性感染性传播感染和早产的风险。在这项研究中，我们研究了正常的健康促进（）和潜在有害（）阴道细菌在实验室环境中如何相互作用。这是为了观察来自 的天然有效物质，可以阻碍 的生长和伴随的免疫反应。我们观察到自行清除，并且通过它产生的几种生化化合物进行清除。由于感染和不当的免疫反应，此类生化化合物可开发为治疗阴道感染和因感染引起的早产的方法。
