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一锅法合成银/季铵盐共修饰介孔二氧化硅纳米粒子用于癌症与细菌感染的协同治疗

One-Pot Synthesis of Ag/Quaternary Ammonium Salt Co-Decorated Mesoporous Silica Nanoparticles for Synergistic Treatment of Cancer and Bacterial Infections.

作者信息

Zhang Hanyuan, Xu Jianxiang, Zhang Xu, Wang Teng, Zhou Dairan, Shu Wei, Zhao Tingting, Fang Weijun

机构信息

Department of Orthopedics, Department of Sports Medicine and Arthroscopic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

出版信息

Front Bioeng Biotechnol. 2022 Jul 19;10:875317. doi: 10.3389/fbioe.2022.875317. eCollection 2022.

DOI:10.3389/fbioe.2022.875317
PMID:35928953
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9344533/
Abstract

Developing drug delivery nanosystems with both anticancer and antibacterial effects is of great clinical value. Herein, we report a facile approach to synthesize Ag and quaternary ammonium salt (QAS) co-decorated mesoporous silica nanoparticles (MSNs), namely, Ag/QAS-MSNs, for synergistic treatment of cancer and bacterial infections. studies demonstrated that Ag/QAS-MSNs not only had a strong antibacterial activity against the bacterial pathogens but also could efficiently induce cancer cell death through an apoptotic pathway. Moreover, combination therapy with Ag and QAS in Ag/QAS-MSNs was also tested in a nude mouse tumor model, and a significant synergistic anticancer effect, which is superior to that obtained by therapy with Ag-MSNs or QAS-MSNs alone, was achieved. Such excellent anticancer and antibacterial activity of Ag/QAS-MSNs could be attributed to the synergistic effect of Ag ions and QAS. Thus, Ag/QAS-MSNs have a promising future as potent anticancer agents with high antibacterial performance.

摘要

开发具有抗癌和抗菌双重作用的药物递送纳米系统具有重要的临床价值。在此，我们报道了一种简便的方法来合成银和季铵盐（QAS）共修饰的介孔二氧化硅纳米颗粒（MSNs），即Ag/QAS-MSNs，用于协同治疗癌症和细菌感染。研究表明，Ag/QAS-MSNs不仅对细菌病原体具有强大的抗菌活性，还能通过凋亡途径有效诱导癌细胞死亡。此外，还在裸鼠肿瘤模型中测试了Ag/QAS-MSNs中银和QAS的联合治疗，结果显示出显著的协同抗癌效果，优于单独使用Ag-MSNs或QAS-MSNs治疗所获得的效果。Ag/QAS-MSNs如此出色的抗癌和抗菌活性可归因于银离子和QAS的协同作用。因此，Ag/QAS-MSNs作为具有高抗菌性能的强效抗癌剂具有广阔的应用前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/441f/9344533/e9b64ad79088/fbioe-10-875317-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/441f/9344533/28808658512e/fbioe-10-875317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/441f/9344533/a9447cb0d9d8/fbioe-10-875317-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/441f/9344533/8f16aa8c8191/fbioe-10-875317-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/441f/9344533/1d267a63b211/fbioe-10-875317-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/441f/9344533/0f8f476b7f99/fbioe-10-875317-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/441f/9344533/aaa0104ec072/fbioe-10-875317-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/441f/9344533/e9b64ad79088/fbioe-10-875317-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/441f/9344533/28808658512e/fbioe-10-875317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/441f/9344533/a9447cb0d9d8/fbioe-10-875317-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/441f/9344533/8f16aa8c8191/fbioe-10-875317-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/441f/9344533/1d267a63b211/fbioe-10-875317-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/441f/9344533/0f8f476b7f99/fbioe-10-875317-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/441f/9344533/aaa0104ec072/fbioe-10-875317-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/441f/9344533/e9b64ad79088/fbioe-10-875317-g007.jpg

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