Babraham Institute, Cambridge, UK.
EMBO J. 2022 Sep 1;41(17):e112181. doi: 10.15252/embj.2022112181. Epub 2022 Aug 5.
Li et al present the results of a proximity-interaction screen in mammalian cells for the effector proteins of 25 members of the Arf family of small GTPases. This study has generated an important resource for those working in several areas of cell biology and provided an initial characterisation of two new cellular roles for some of the least well studied members of this family, the regulation of PLD1 by ARL11/14 in phagocytosis, and the regulation of PI4KB by ARL5A/5B in the Golgi.
李等人在哺乳动物细胞中展示了 25 种 Arf 家族小 GTPase 的效应蛋白的接近相互作用筛选结果。这项研究为细胞生物学的多个领域的研究人员提供了一个重要的资源,并初步确定了这个家族中研究最少的成员的两个新的细胞功能,即 ARL11/14 在吞噬作用中对 PLD1 的调节,以及 ARL5A/5B 在高尔基体中对 PI4KB 的调节。