Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710054, China.
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710054, China.
Biomater Adv. 2022 Apr;135:212737. doi: 10.1016/j.bioadv.2022.212737. Epub 2022 Apr 22.
Highly efficient wound healing and skin regeneration remain a challenge. Long-term inflammation and bacterial infection can inhibit the healing process and lead to the scar formation. Here, we report a hydrogel (FEM) formed by self-assembly of ε-poly-l-lysine-F127-ε-poly-l-lysine (EPL-F127-EPL) and metformin for wound repair. Especially, the role of metformin-based antibacterial hydrogel in wound healing and repair was investigated for the first time. FEM has inherent multifunctional properties, including controlled metformin release, anti-inflammatory and antibacterial activity, temperature responsiveness, injectable and self-healing capabilities. The in vivo results showed that FEM dressings accelerated the wound healing by stimulating the angiogenesis process of the wound tissue and anti-inflammation. This study shows that the multifunctional metformin-contained hydrogel scaffolds could enhance the wound repair through the anti-inflammation and accelerated angiogenesis, which could also expand the biomedical applications of metformin-based biomaterials.
高效的伤口愈合和皮肤再生仍然是一个挑战。长期的炎症和细菌感染会抑制愈合过程，导致疤痕形成。在这里，我们报告了一种由 ε-聚赖氨酸-F127-ε-聚赖氨酸（EPL-F127-EPL）自组装形成的水凝胶（FEM），并将其用于伤口修复。特别是，首次研究了基于二甲双胍的抗菌水凝胶在伤口愈合和修复中的作用。FEM 具有固有的多功能特性，包括控制二甲双胍的释放、抗炎和抗菌活性、温度响应性、可注射性和自修复能力。体内结果表明，FEM 敷料通过刺激伤口组织的血管生成过程和抗炎作用来加速伤口愈合。这项研究表明，含有多功能二甲双胍的水凝胶支架可以通过抗炎和加速血管生成来增强伤口修复，这也可以扩展基于二甲双胍的生物材料的生物医学应用。
