Blaschke G, Hilgard P, Maibaum J, Niemeyer U, Pohl J
Arzneimittelforschung. 1986 Oct;36(10):1493-5.
The enantiomers of ifosfamide were isolated chromatographically by the use of an optically active adsorbent. The biological activities of the racemic product and of the enantiomers (+)- and (-)-ifosfamide were compared as to the acute toxicity after single intraperitoneal administration on mice. Futhermore, the antitumor activity has been compared with regard to the rat leukemia L 5222 and the haematotoxicological effect. Under the conditions given, no biological differences between these 3 ifosfamide preparations were observed.
通过使用旋光吸附剂，以色谱法分离异环磷酰胺的对映体。比较了外消旋产物以及对映体（+）-和（-）-异环磷酰胺单次腹腔注射给小鼠后的急性毒性的生物活性。此外，还比较了对大鼠白血病L 5222的抗肿瘤活性和血液毒理学效应。在给定条件下，未观察到这三种异环磷酰胺制剂之间存在生物学差异。
