Key Laboratory of Eco-textiles, Ministry of Education, Jiangnan University, Wuxi, People's Republic of China.
Key Laboratory of Eco-textiles, Ministry of Education, Jiangnan University, Wuxi, People's Republic of China.
Biomater Adv. 2022 May;136:212799. doi: 10.1016/j.bioadv.2022.212799. Epub 2022 Apr 11.
Numerous tissues in the human body have fibrous structures, including the extracellular matrix, muscles, and heart, which perform critical biological functions and have exceptional mechanical strength. Due to their high-water content, softness, biocompatibility and elastic nature, hydrogels resemble biological tissues. Traditional hydrogels, on the other hand, have weak mechanical properties and lack tissue-like fibrous structures, limiting their potential applications. Thus, bio-inspired hydrogels with fibrous architectures have piqued the curiosity of biomedical researchers. Here, we review fabrication strategies for fibrous hydrogels and their recent progress in the biomedical fields of wound dressings, drug delivery, tissue engineering scaffolds and bioadhesives. Challenges and future perspectives are also discussed.
人体内有许多组织都具有纤维结构，包括细胞外基质、肌肉和心脏，它们执行着关键的生物学功能，并且具有非凡的机械强度。水凝胶类似于生物组织，具有高含水量、柔软性、生物相容性和弹性。然而，传统水凝胶的机械性能较弱，缺乏类似组织的纤维结构，限制了它们的潜在应用。因此，具有纤维状结构的仿生水凝胶引起了生物医学研究人员的兴趣。在这里，我们综述了纤维水凝胶的制备策略及其在伤口敷料、药物输送、组织工程支架和生物粘合剂等生物医学领域的最新进展。还讨论了挑战和未来展望。
