Department of Orthopaedics, University J. E. Purkinje and Masaryk Hospital, Usti nad Labem, Czech Republic.
Department of Biomedicine and Laboratory Diagnostics, University J. E. Purkinje and Masaryk Hospital, Usti nad Labem, Czech Republic.
Int J Rheum Dis. 2022 Nov;25(11):1324-1327. doi: 10.1111/1756-185X.14411. Epub 2022 Aug 5.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus 2019 disease (COVID-19) have spread all around the world since 2019 and have affected millions of people. The development of COVID-19 vaccines helped to decelerate the spread of the virus. However, as in the case of vaccines against other infectious diseases, adverse events can also present with COVID-19 vaccines.
We report here a rare case of a 53-year-old man with knee-joint synovitis, after the first dose of messenger RNA vaccine, with no fever and a negative COVID-19 reverse transcription polymerase chain reaction test. During a clinical examination the suspicion of pyogenic arthritis was excluded by blood tests and by a complex joint effusion examination, including a microbiological and cytological-energy analysis of the synovial fluid. The treatment received by our patient consisted of 3 doses of dexamethasone administered intravenously over a period of 3 days. All the symptoms improved after this therapy, and in the 3-week follow-up period we recorded full recovery with no consequences.
Case reports on patients undergoing COVID-19 vaccination should be examined in order to detect rare and long-term side-effects. This is the first report to present the outcomes of an ultrastructural analysis of post-vaccination synovitis.
自 2019 年以来，严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染及其导致的 2019 年冠状病毒病（COVID-19）已在全球范围内传播，并影响了数百万人。COVID-19 疫苗的开发有助于减缓病毒的传播。然而，就像针对其他传染病的疫苗一样，COVID-19 疫苗也会出现不良反应。
我们在此报告一例罕见病例，一名 53 岁男性在接种第一剂信使 RNA 疫苗后出现膝关节滑膜炎，无发热，COVID-19 逆转录聚合酶链反应检测结果为阴性。临床检查排除了菌性关节炎的可能，血液检查和关节积液综合检查（包括关节滑液的微生物学和细胞学能量分析）排除了这种可能性。我们的患者接受了 3 剂地塞米松静脉注射治疗，持续 3 天。经过这种治疗后，所有症状均得到改善，在 3 周的随访期间，我们记录到完全康复，无任何后遗症。
应检查接受 COVID-19 疫苗接种的患者病例，以发现罕见和长期的副作用。这是首例报告 COVID-19 疫苗接种后滑膜炎超微结构分析结果的病例。
