• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

滑液中脓性炎症的细胞学能量检测并非非黑即白。

The Cytological Energy Detection of Purulent Inflammation in Synovial Fluid Is Not All Black and White.

作者信息

Kelbich Petr, Vanaskova Eliska, Hrach Karel, Krejsek Jan, Smisko Frantisek, Hruskova Pavla, Hanuljakova Eva, Novotny Tomas

机构信息

Department of Biomedicine and Laboratory Diagnostics, Faculty of Health Studies, Jan Evangelista Purkinje University and Masaryk Hospital, 401 13 Usti nad Labem, Czech Republic.

Department of Clinical Immunology and Allergology, Faculty of Medicine and University Hospital, Charles University in Prague, 500 03 Hradec Kralove, Czech Republic.

出版信息

Biomedicines. 2024 Mar 16;12(3):667. doi: 10.3390/biomedicines12030667.

DOI:10.3390/biomedicines12030667
PMID:38540280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10968347/
Abstract

Neutrophils are frequently found in the cytological picture of synovial fluid in several joint pathologies, and a higher proportion of them can even wrongly indicate these cases as purulent inflammation. For reliable differentiation between purulent and non-purulent cases, we use the cytological energy analysis of the synovial fluid. Using this method, we examined 350 knee joint synovial fluid samples. Overall, we found that the percentage of neutrophils ranged between 20.0% and 50.0% in 44 (12.6%) cases and was above 50.0% in 231 (66.0%) cases. In the same group, only 85 (24.3%) highly anaerobic synovial fluid samples were evaluated as purulent inflammation, and another 17 (4.9%) cases were evaluated as very likely purulent inflammation. Further, we quantified the immediate risk of purulent inflammation using the "purulent score" (PS). Of the total of 350 samples, 103 (29.4%) cases were classified as having a very high risk of purulent inflammation (PS = 4), 53 (15.1%) cases were classified as having a significant risk of purulent inflammation (PS = 3), 17 (4.9%) cases were classified as having a moderate risk of purulent inflammation (PS = 2), and 75 (21.4%) cases were classified as having no immediate risk of purulent inflammation (PS = 1). Based on our results and analyses, the cytological energy analysis of synovial fluid is an effective method that can be used to detect and specify joint inflammation and the risk of septic arthritis development.

摘要

在几种关节病变的滑液细胞学图像中经常发现中性粒细胞，甚至较高比例的中性粒细胞会错误地将这些病例指示为脓性炎症。为了可靠地区分脓性和非脓性病例，我们使用滑液的细胞能量分析。使用这种方法，我们检查了350份膝关节滑液样本。总体而言，我们发现44例（12.6%）中性粒细胞百分比在20.0%至50.0%之间，231例（66.0%）中性粒细胞百分比高于50.0%。在同一组中，只有85份（24.3%）高度厌氧的滑液样本被评估为脓性炎症，另有17例（4.9%）被评估为极有可能是脓性炎症。此外，我们使用“脓性评分”（PS）对脓性炎症的即时风险进行了量化。在总共350个样本中，103例（29.4%）被分类为脓性炎症风险非常高（PS = 4），53例（15.1%）被分类为脓性炎症风险显著（PS = 3），17例（4.9%）被分类为脓性炎症风险中等（PS = 2），75例（21.4%）被分类为无脓性炎症即时风险（PS = 1）。根据我们的结果和分析，滑液的细胞能量分析是一种有效的方法，可用于检测和明确关节炎症以及脓毒性关节炎发展的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08f/10968347/933d987eaffa/biomedicines-12-00667-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08f/10968347/65396c909891/biomedicines-12-00667-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08f/10968347/d9fc1d70d2c3/biomedicines-12-00667-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08f/10968347/0ee09f33a182/biomedicines-12-00667-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08f/10968347/0653d56cdf94/biomedicines-12-00667-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08f/10968347/ba05e8675de5/biomedicines-12-00667-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08f/10968347/b6c2030cfa0f/biomedicines-12-00667-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08f/10968347/933d987eaffa/biomedicines-12-00667-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08f/10968347/65396c909891/biomedicines-12-00667-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08f/10968347/d9fc1d70d2c3/biomedicines-12-00667-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08f/10968347/0ee09f33a182/biomedicines-12-00667-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08f/10968347/0653d56cdf94/biomedicines-12-00667-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08f/10968347/ba05e8675de5/biomedicines-12-00667-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08f/10968347/b6c2030cfa0f/biomedicines-12-00667-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08f/10968347/933d987eaffa/biomedicines-12-00667-g007.jpg

相似文献

1
The Cytological Energy Detection of Purulent Inflammation in Synovial Fluid Is Not All Black and White.滑液中脓性炎症的细胞学能量检测并非非黑即白。
Biomedicines. 2024 Mar 16;12(3):667. doi: 10.3390/biomedicines12030667.
2
Neutrophils in Extravascular Body Fluids: Cytological-Energy Analysis Enables Rapid, Reliable and Inexpensive Detection of Purulent Inflammation and Tissue Damage.血管外体液中的中性粒细胞：细胞能量分析可实现对脓性炎症和组织损伤的快速、可靠且低成本检测。
Life (Basel). 2022 Jan 21;12(2):160. doi: 10.3390/life12020160.
3
The importance of urgent cytological examination of synovial fluids in differentiation inflammatory and non-inflammatory joint diseases.滑膜液紧急细胞学检查在鉴别炎性和非炎性关节疾病中的重要性。
Coll Antropol. 2010 Mar;34(1):145-52.
4
Cytological-energy analysis of pleural effusions with predominance of neutrophils.以中性粒细胞为主的胸腔积液细胞能量分析。
Ther Adv Respir Dis. 2020 Jan-Dec;14:1753466620935772. doi: 10.1177/1753466620935772.
5
Synovial fluid findings in children with knee monoarthritis in lyme disease endemic areas.莱姆病流行地区膝单关节炎患儿的滑液检查结果
Pediatr Emerg Care. 2014 Jan;30(1):16-9. doi: 10.1097/PEC.0000000000000028.
6
Beta defensins as biomarkers: detectable in LPS-stimulated equine peripheral blood mononuclear cells and normal, aseptic, and probable septic equine synovial fluid.β防御素作为生物标志物：在 LPS 刺激的马外周血单个核细胞和正常、无菌和可能感染性马关节液中可检测到。
Am J Vet Res. 2022 Jul 20;83(9):ajvr.21.12.0204. doi: 10.2460/ajvr.21.12.0204.
7
The natural progression of synovial fluid white blood-cell counts and the percentage of polymorphonuclear cells after primary total knee arthroplasty: a multicenter study.初次全膝关节置换术后滑液白细胞计数和多形核细胞百分比的自然演变：一项多中心研究。
J Bone Joint Surg Am. 2013 Dec 4;95(23):2081-7. doi: 10.2106/JBJS.L.01646.
8
Interleukin-6 in serum and in synovial fluid enhances the differentiation between periprosthetic joint infection and aseptic loosening.血清和滑液中的白细胞介素-6 增强了假体周围关节感染和无菌性松动的鉴别诊断。
PLoS One. 2014 Feb 21;9(2):e89045. doi: 10.1371/journal.pone.0089045. eCollection 2014.
9
Basic Analysis of the Cerebrospinal Fluid: An Important Framework for Laboratory Diagnostics of the Impairment of the Central Nervous System.脑脊液的基本分析：中枢神经系统损伤实验室诊断的重要框架。
Curr Issues Mol Biol. 2022 Aug 14;44(8):3666-3680. doi: 10.3390/cimb44080251.
10
Septic arthritis due to non-tuberculous mycobacterium without effusion.非结核分枝杆菌引起的无渗出性化脓性关节炎。
Am J Emerg Med. 2021 May;43:287.e5-287.e7. doi: 10.1016/j.ajem.2020.09.043. Epub 2020 Sep 23.

本文引用的文献

1
Guideline for management of septic arthritis in native joints (SANJO).原发性关节化脓性关节炎（SANJO）管理指南
J Bone Jt Infect. 2023 Jan 12;8(1):29-37. doi: 10.5194/jbji-8-29-2023. eCollection 2023.
2
Reliable Diagnostic Tests and Thresholds for Preoperative Diagnosis of Non-Inflammatory Arthritis Periprosthetic Joint Infection: A Meta-analysis and Systematic Review.可靠的诊断检测方法和术前非炎性关节炎人工关节置换术后感染阈值：荟萃分析和系统评价。
Orthop Surg. 2022 Nov;14(11):2822-2836. doi: 10.1111/os.13500. Epub 2022 Oct 1.
3
Reactive synovitis of the knee joint after COVID-19 vaccination: The first ultrastructural analysis of synovial fluid.
COVID-19 疫苗接种后膝关节反应性滑膜炎：滑液的首次超微结构分析。
Int J Rheum Dis. 2022 Nov;25(11):1324-1327. doi: 10.1111/1756-185X.14411. Epub 2022 Aug 5.
4
Neutrophils in Extravascular Body Fluids: Cytological-Energy Analysis Enables Rapid, Reliable and Inexpensive Detection of Purulent Inflammation and Tissue Damage.血管外体液中的中性粒细胞：细胞能量分析可实现对脓性炎症和组织损伤的快速、可靠且低成本检测。
Life (Basel). 2022 Jan 21;12(2):160. doi: 10.3390/life12020160.
5
Toxocariasis as a Rare Parasitic Complication of a Transthoracic Spine Surgery Procedure.胸腔脊柱手术罕见寄生虫并发症：弓蛔虫病。
Medicina (Kaunas). 2021 Dec 3;57(12):1328. doi: 10.3390/medicina57121328.
6
Performance of a new rapid diagnostic test the lactate/glucose ratio of synovial fluid for the diagnosis of septic arthritis.新的快速诊断试验——滑液乳酸/葡萄糖比值在诊断化脓性关节炎中的性能。
Joint Bone Spine. 2020 Jul;87(4):343-350. doi: 10.1016/j.jbspin.2020.03.009. Epub 2020 Mar 29.
7
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?中性粒细胞：在炎症中扮演多种角色的一种细胞还是多种细胞类型？
Front Physiol. 2018 Feb 20;9:113. doi: 10.3389/fphys.2018.00113. eCollection 2018.
8
Inflammatory responses and inflammation-associated diseases in organs.器官中的炎症反应及炎症相关疾病。
Oncotarget. 2017 Dec 14;9(6):7204-7218. doi: 10.18632/oncotarget.23208. eCollection 2018 Jan 23.
9
Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance.中性粒细胞拯救活性氧：NADPH 氧化酶激活和细菌耐药的机制。
Front Cell Infect Microbiol. 2017 Aug 25;7:373. doi: 10.3389/fcimb.2017.00373. eCollection 2017.
10
The phagocyte respiratory burst: Historical perspectives and recent advances.吞噬细胞呼吸爆发：历史透视与最新进展。
Immunol Lett. 2017 Dec;192:88-96. doi: 10.1016/j.imlet.2017.08.016. Epub 2017 Aug 31.