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Immunobiological and antiinflammatory properties of 1-phenylo-2-thioxo-3-diethylo-aminoethylo-4-ox o-7-methylpyrimido- [4,5-c]-pyrimidine hydrochloride (compound I).

作者信息

Giełdanowski J, Raberger G, Kowalczyk-Bronisz S H

出版信息

Arch Immunol Ther Exp (Warsz). 1986;34(3):351-68.

PMID:3592937
Abstract

Immunological and pharmacological properties of 1-phenylo-2-thioxo-3-diethylo-aminoethylo-4-oxo- 7-methylpyrimido [4,5-c]-pyrimidine hydrochloride were evaluated. The preparation was observed to exert immunotropic, predominantly suppressive effect as well as nonspecific antiinflammatory effect. This was accompanied by hardly perceptible central component and slight, reversible effect on the circulatory system. The trials to elucidate mechanism of activity of the immunotropic preparation revealed that it attacked immunologically committed cells. However, it does not act on suppressor cells.

摘要

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