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坏死性小肠结肠炎的诊断与治疗综述

A Review of the Diagnosis and Treatment of Necrotizing Enterocolitis.

作者信息

Cai Xue, Liebe Heather L, Golubkova Alena, Leiva Tyler, Hunter Catherine J

机构信息

Department of Surgery, The University of Oklahoma Health Sciences Center, 800 Research Parkway Suite 449, Oklahoma City, OK 73104, Japan.

Division of Pediatric Surgery, Oklahoma Children's Hospital, Oklahoma City, OK 73104, Japan.

出版信息

Curr Pediatr Rev. 2023;19(3):285-295. doi: 10.2174/1573396318666220805110947.

DOI:10.2174/1573396318666220805110947
PMID:35929629
Abstract

Necrotizing enterocolitis (NEC) is a devastating disease that primarily affects the gastrointestinal tract of premature neonates. The diagnosis and treatment of NEC remain challenging. New biomarkers and potential treatments for NEC have emerged in recent years, leading to the potential of earlier therapeutic intervention and improved outcomes. This paper aims to provide a review of the most recent diagnostic indicators and therapeutics of NEC along with a brief overview of future directions of research into this disease.

摘要

坏死性小肠结肠炎(NEC)是一种主要影响早产儿胃肠道的毁灭性疾病。NEC的诊断和治疗仍然具有挑战性。近年来出现了NEC的新生物标志物和潜在治疗方法,这使得早期治疗干预和改善预后成为可能。本文旨在综述NEC的最新诊断指标和治疗方法,并简要概述该疾病未来的研究方向。

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1
A Review of the Diagnosis and Treatment of Necrotizing Enterocolitis.坏死性小肠结肠炎的诊断与治疗综述
Curr Pediatr Rev. 2023;19(3):285-295. doi: 10.2174/1573396318666220805110947.
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Evolving understanding of neonatal necrotizing enterocolitis.新生儿坏死性小肠结肠炎的认识进展。
Curr Opin Pediatr. 2018 Jun;30(3):417-423. doi: 10.1097/MOP.0000000000000629.
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[Clinical guidelines for the diagnosis and treatment of neonatal necrotizing enterocolitis (2020)].[新生儿坏死性小肠结肠炎诊断与治疗临床指南(2020年版)]
Zhongguo Dang Dai Er Ke Za Zhi. 2021 Jan;23(1):1-11. doi: 10.7499/j.issn.1008-8830.2011145.
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Necrotizing enterocolitis.坏死性小肠结肠炎。
Neurogastroenterol Motil. 2019 Mar;31(3):e13569. doi: 10.1111/nmo.13569.
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Biobanking for necrotizing enterocolitis: Needs and standards.用于坏死性小肠结肠炎的生物库:需求与标准。
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Necrotizing Enterocolitis: Enhancing Awareness for the General Practitioner.坏死性小肠结肠炎:提高全科医生的认识
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Development of the necrotizing enterocolitis society registry and biorepository.坏死性小肠结肠炎协会登记处和生物样本库的发展。
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Necrotizing enterocolitis in premature infants and newborns.早产儿和新生儿坏死性小肠结肠炎
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Hemophagocytic lymphohistiocytosis associated with necrotizing enterocolitis in premature newborns.早产生儿坏死性小肠结肠炎相关噬血细胞性淋巴组织细胞增生症。
Pediatr Blood Cancer. 2012 Aug;59(2):315-7. doi: 10.1002/pbc.23381. Epub 2012 Feb 7.
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Necrotizing enterocolitis.坏死性小肠结肠炎。
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引用本文的文献

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Necrotizing enterocolitis: specific human milk oligosaccharides prevent enteric glia loss and hypomotility.坏死性小肠结肠炎:特定的人乳寡糖可预防肠神经胶质细胞损失和肠道运动减弱。
Pediatr Res. 2025 May 10. doi: 10.1038/s41390-025-04077-y.
2
Risk of neurodevelopmental impairment in Swedish preterm children treated for necrotizing enterocolitis: retrospective cohort study.瑞典接受坏死性小肠结肠炎治疗的早产儿发生神经发育障碍的风险:回顾性队列研究。
BJS Open. 2024 Oct 29;8(6). doi: 10.1093/bjsopen/zrae131.
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Redox Chemistry: Implications for Necrotizing Enterocolitis.
氧化还原化学:对坏死性小肠结肠炎的影响。
Int J Mol Sci. 2024 Aug 1;25(15):8416. doi: 10.3390/ijms25158416.
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Extracellular Nicotinamide Phosphoribosyltransferase Is a Therapeutic Target in Experimental Necrotizing Enterocolitis.细胞外烟酰胺磷酸核糖转移酶是实验性坏死性小肠结肠炎的治疗靶点。
Biomedicines. 2024 Apr 28;12(5):970. doi: 10.3390/biomedicines12050970.