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[Clinical guidelines for the diagnosis and treatment of neonatal necrotizing enterocolitis (2020)].[新生儿坏死性小肠结肠炎诊断与治疗临床指南（2020年版）]
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2
Development of an international core outcome set for treatment trials in necrotizing enterocolitis-a study protocol.制定坏死性小肠结肠炎治疗试验国际核心结局集：研究方案。
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Neonatal necrotizing enterocolitis: a focus on.新生儿坏死性小肠结肠炎：聚焦于……
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A Review of the Diagnosis and Treatment of Necrotizing Enterocolitis.坏死性小肠结肠炎的诊断与治疗综述
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Necrotizing enterocolitis: current understanding of the prevention and management.坏死性小肠结肠炎：预防和管理的最新认识。
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Necrotizing enterocolitis - classification and two initial steps towards prevention.坏死性小肠结肠炎——分类及预防的两个初步措施
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Hyponatremia at the onset of necrotizing enterocolitis is associated with intestinal surgery and higher mortality.坏死性小肠结肠炎发病时出现低钠血症与肠道手术和更高的死亡率相关。
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Current pain management practices for preterm infants with necrotizing enterocolitis: a European survey.目前对患有坏死性小肠结肠炎的早产儿的疼痛管理措施：一项欧洲调查。
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Utility of transforming growth factor beta-1 in diagnosis of neonatal necrotizing enterocolitis.转化生长因子-β1 在新生儿坏死性小肠结肠炎诊断中的作用。
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Necrotizing enterocolitis.坏死性小肠结肠炎。
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Predictive value of serum markers in the operation evaluation of neonatal necrotizing enterocolitis.血清标志物在新生儿坏死性小肠结肠炎手术评估中的预测价值
Transl Pediatr. 2023 May 30;12(5):897-906. doi: 10.21037/tp-23-56. Epub 2023 May 25.
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[Antibiotic use in very low birth weight/extremely low birth weight infants in 15 hospitals in Jiangsu Province of China: a multicenter survey].[中国江苏省15家医院极低出生体重/超低出生体重婴儿的抗生素使用情况：一项多中心调查]
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本文引用的文献

1
Strategies to increase the use of mother's own milk for infants at risk of necrotizing enterocolitis.增加患有坏死性小肠结肠炎风险的婴儿使用母乳的策略。
Pediatr Res. 2020 Aug;88(Suppl 1):21-24. doi: 10.1038/s41390-020-1075-3.
2
Earlier re-initiation of enteral feeding after necrotizing enterocolitis decreases recurrence or stricture: a systematic review and meta-analysis.早期重新开始坏死性小肠结肠炎后的肠内喂养可降低复发或狭窄的风险：系统评价和荟萃分析。
J Perinatol. 2020 Nov;40(11):1679-1687. doi: 10.1038/s41372-020-0722-1. Epub 2020 Jul 18.
3
Normative values for circulating intestinal fatty acid binding protein and calprotectin across gestational ages.不同孕期循环肠脂肪酸结合蛋白和钙卫蛋白的参考值范围。
BMC Pediatr. 2020 May 26;20(1):250. doi: 10.1186/s12887-020-02142-5.
4
Probiotic Use and Safety in the Neonatal Intensive Care Unit: A Matched Cohort Study.益生菌在新生儿重症监护病房的使用与安全性：一项匹配队列研究。
J Pediatr. 2020 Jul;222:59-64.e1. doi: 10.1016/j.jpeds.2020.03.051. Epub 2020 May 14.
5
The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial.乳铁蛋白补充对极低出生体重儿（LIFT）死亡或主要发病率的影响：一项多中心、双盲、随机对照试验。
Lancet Child Adolesc Health. 2020 Jun;4(6):444-454. doi: 10.1016/S2352-4642(20)30093-6. Epub 2020 May 12.
6
Low Splanchnic Oxygenation and Risk for Necrotizing Enterocolitis in Extremely Preterm Newborns.极低出生体重儿内脏低氧血症与坏死性小肠结肠炎风险的相关性研究
J Pediatr Gastroenterol Nutr. 2020 Sep;71(3):401-406. doi: 10.1097/MPG.0000000000002761.
7
Probiotics and Preterm Infants: A Position Paper by the European Society for Paediatric Gastroenterology Hepatology and Nutrition Committee on Nutrition and the European Society for Paediatric Gastroenterology Hepatology and Nutrition Working Group for Probiotics and Prebiotics.益生菌与早产儿：欧洲儿科胃肠病学、肝病学和营养学学会营养委员会与益生菌和预生物工作组的立场文件
J Pediatr Gastroenterol Nutr. 2020 May;70(5):664-680. doi: 10.1097/MPG.0000000000002655.
8
Preterm Infants Fed Cow's Milk-Derived Fortifier Had Adverse Outcomes Despite a Base Diet of Only Mother's Own Milk.尽管早产儿的基础饮食仅为母亲自身的母乳，但喂食牛奶衍生的强化剂仍会导致不良后果。
Breastfeed Med. 2020 May;15(5):297-303. doi: 10.1089/bfm.2019.0133. Epub 2020 Apr 2.
9
Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants.肠内补充乳铁蛋白预防早产儿败血症和坏死性小肠结肠炎
Cochrane Database Syst Rev. 2020 Mar 31;3(3):CD007137. doi: 10.1002/14651858.CD007137.pub6.
10
Mortality and Morbidity in Infants <34 Weeks' Gestation in 25 NICUs in China: A Prospective Cohort Study.中国25家新生儿重症监护病房中孕周<34周婴儿的死亡率和发病率：一项前瞻性队列研究
Front Pediatr. 2020 Feb 13;8:33. doi: 10.3389/fped.2020.00033. eCollection 2020.

[新生儿坏死性小肠结肠炎诊断与治疗临床指南（2020年版）]

[Clinical guidelines for the diagnosis and treatment of neonatal necrotizing enterocolitis (2020)].

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2021 Jan;23(1):1-11. doi: 10.7499/j.issn.1008-8830.2011145.

DOI:10.7499/j.issn.1008-8830.2011145
PMID:33476530
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7818154/
Abstract

Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of neonates, especially of preterm infants, with high morbidity and mortality. The surviving infants may have digestive tract and neurological sequelae. Therefore, the prevention and treatment of NEC are of great significance in improving survival rate and survival quality of neonates. To provide evidence-based recommendations for management of NEC, the guidelines were developed based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) and the current domestic and overseas studies.

摘要

坏死性小肠结肠炎（NEC）是一种严重的新生儿胃肠道疾病，尤其是早产儿，其发病率和死亡率很高。存活的婴儿可能会有消化道和神经后遗症。因此，NEC的防治对提高新生儿的存活率和生存质量具有重要意义。为了为NEC的管理提供循证建议，本指南基于推荐评估、制定与评价分级（GRADE）以及当前国内外研究制定。