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LncRNA 作为竞争性内源性 RNA 上调甲状腺乳头状癌中的 。

LncRNA serves as a competing endogenous RNA of to upregulate in papillary thyroid carcinoma.

机构信息

Department of Pathology, Affiliated 3201 Hospital of Xi'an Jiaotong University, Hanzhong City, Shaanxi Province, PR China.

Department of Pathology, Affiliated 3201 Hospital of Xi'an Jiaotong University, Hanzhong City, Shaanxi Province, PR China,

出版信息

Arch Endocrinol Metab. 2023 Jan 18;67(1):55-63. doi: 10.20945/2359-3997000000510. Epub 2022 Aug 4.

DOI:10.20945/2359-3997000000510
PMID:35929906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9983800/
Abstract

OBJECTIVE

has been characterized as an oncogenic long non-coding RNA (lncRNA) in several cancers including papillary thyroid cancer (PTC), but its role in PTC has not been fully elucidated. Considering the critical role of lncRNAs in cancer biology, further functional analysis of in PTC may provide novel insights into PTC management.

SUBJECTS AND METHODS

Paired tumor and non-tumor tissues were collected from 63 papillary thyroid carcinoma (PTC) patients. Expression levels of and in tissue samples were analyzed by qRT-PCR. Cell transfection was performed to explore the interactions among and . Cell proliferation assay was performed to evaluate the effects of and on cell proliferation.

RESULTS

accumulated to high levels in PTC tissues and was affected by clinical stage. showed a positive correlation with across PTC tissues. RNA interaction prediction showed that could bind to , which can directly target . and showed no regulatory role regulating the expression of each other, but overexpression of upregulated and enhanced cell proliferation. In contrast, overexpression of miR-218 downregulated and attenuated cell proliferation. In addition, miR-218 suppressed the role of in regulating the expression of and cell proliferation.

CONCLUSION

may serve as a competing endogenous RNA of to upregulate in PTC, thereby promoting cell proliferation. The pathway characterized in the present study might serve as a potential target to treat PTC.

摘要

目的

在多种癌症中，已被鉴定为致癌性长非编码 RNA（lncRNA），包括甲状腺乳头状癌（PTC），但其在 PTC 中的作用尚未完全阐明。鉴于 lncRNAs 在癌症生物学中的关键作用，对 PTC 中 的进一步功能分析可能为 PTC 管理提供新的见解。

受试者和方法

从 63 例甲状腺乳头状癌（PTC）患者中收集配对的肿瘤和非肿瘤组织。通过 qRT-PCR 分析组织样本中 和 的表达水平。通过细胞转染探索 和 之间的相互作用。通过细胞增殖测定评估 和 对细胞增殖的影响。

结果

在 PTC 组织中大量积累，并受临床分期的影响。 在 PTC 组织中与 呈正相关。RNA 相互作用预测显示 可以与 结合， 可以直接靶向 。 和 对彼此的表达没有调节作用，但 的过表达上调了 和增强了细胞增殖。相比之下，miR-218 的过表达下调了 和减弱了细胞增殖。此外，miR-218 抑制了 在调节 表达和细胞增殖中的作用。

结论

可能作为 的竞争性内源性 RNA，在上调 PTC 中的 表达，从而促进细胞增殖。本研究中表征的 途径可能作为治疗 PTC 的潜在靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbcd/9983800/42e791b1d21e/2359-4292-aem-67-01-0055-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbcd/9983800/495ab97657f5/2359-4292-aem-67-01-0055-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbcd/9983800/5521e19c697d/2359-4292-aem-67-01-0055-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbcd/9983800/6fbae9353ce6/2359-4292-aem-67-01-0055-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbcd/9983800/33d36f736a5f/2359-4292-aem-67-01-0055-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbcd/9983800/3d24f0fcc3e5/2359-4292-aem-67-01-0055-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbcd/9983800/42e791b1d21e/2359-4292-aem-67-01-0055-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbcd/9983800/495ab97657f5/2359-4292-aem-67-01-0055-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbcd/9983800/5521e19c697d/2359-4292-aem-67-01-0055-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbcd/9983800/6fbae9353ce6/2359-4292-aem-67-01-0055-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbcd/9983800/33d36f736a5f/2359-4292-aem-67-01-0055-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbcd/9983800/3d24f0fcc3e5/2359-4292-aem-67-01-0055-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbcd/9983800/42e791b1d21e/2359-4292-aem-67-01-0055-gf06.jpg

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