Wang Cheng, Li Feng, Li Yang, Feng Hui, Zhao Min-Wei, Tu Peng-Fei, Tian Hua
Department of Orthopaedics/Engineering Research Center of Bone and Joint Precision Medicine/Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, Beijing, 100191, China.
Peking University School of Pharmaceutical Sciences, Beijing, 100191, China.
Chin J Integr Med. 2023 Jan;29(1):74-80. doi: 10.1007/s11655-022-3518-z. Epub 2022 Aug 5.
Osteoporosis is a generalized disease of bone that leads to a loss of bone density and bone mass, destruction of bone microstructure, increased brittleness and therefore fracture. At present, the main treatment of Western medicine is drug therapy such as bisphosphonates, calcitriol, vitamin D, etc. However, long-term use of these drugs may bring some adverse reactions. Chinese herbal medicine Cistanche deserticola could regulate bone metabolism by promoting osteoblast activity and inhibiting osteoclast activity with low toxicity and adverse reactions. Therefore, Cistanche deserticola has attracted increasing attention for its efficacy in the prevention and treatment of osteoporosis in recent years. Here we present a literature review of the molecular pathways involved in osteoporosis and the effects of Cistanche deserticola on bone metabolism. Our objective is to clarify the mechanism of Cistanche deserticola in the treatment of osteoporosis.
骨质疏松症是一种全身性骨骼疾病，会导致骨密度和骨量降低、骨微结构破坏、脆性增加，进而引发骨折。目前，西医的主要治疗方法是药物治疗，如双膦酸盐、骨化三醇、维生素D等。然而，长期使用这些药物可能会带来一些不良反应。中药肉苁蓉可通过促进成骨细胞活性和抑制破骨细胞活性来调节骨代谢，且毒性和不良反应较低。因此，近年来肉苁蓉因其在预防和治疗骨质疏松症方面的功效而受到越来越多的关注。在此，我们对骨质疏松症涉及的分子途径以及肉苁蓉对骨代谢的影响进行文献综述。我们的目的是阐明肉苁蓉治疗骨质疏松症的机制。
