, Private Practice in Dentistry, Porto Alegre, Brazil.
Programa de Pós-graduação em Odontologia, Faculdade de Odontologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Clin Oral Investig. 2022 Nov;26(11):6829-6837. doi: 10.1007/s00784-022-04644-1. Epub 2022 Aug 5.
This study aimed to identify medications taken by patients before dental appointments and to simulate and characterize their interactions with medications often prescribed by dental surgeons.
A retrospective cross-sectional study evaluated 320 medical records, 118 from the Emergency Service (ES) archives, and 202 from elective appointments at the Dental Clinic (DC) of a university in southern Brazil. Drug interactions were identified and classified according to severity using the Medscape® application into four grades: (1) Minor, (2) Monitor closely, (3) Serious, or (4) Contraindicated. Descriptive and inferential statistical analyses were carried out (α = 5%).
Preexisting systemic conditions were noted in 55.9% of the medical records from the ES and 64.35% from the DC. In the ES records, 47.45% contained information on continuous use medication for treatment of systemic conditions and 59.40% of DC records contained such information. A total of 359 potential interactions were found. Drug interactions with analgesics were most frequent, accounting for 50.41% of the sample.
The most prevalent drug interaction severity was grade 2: monitor or use with caution. Many patients take medications to treat systemic conditions and seek dental care, generating a significant possible source of drug interactions.
Prescribers must carefully analyze the patients' medical histories and obtain accurate data regarding their use of medications to be able to assess the risk-benefit relationships of possible combinations.
本研究旨在识别患者在看牙前服用的药物，并模拟和描述其与牙医常开药物的相互作用。
回顾性横断面研究评估了 320 份病历，其中 118 份来自急诊（ES）档案，202 份来自巴西南部一所大学牙科诊所（DC）的择期预约。使用 Medscape®应用程序根据严重程度将药物相互作用分为四个等级（1）轻度、（2）密切监测、（3）严重或（4）禁忌，并识别和分类。进行了描述性和推断性统计分析（α=5%）。
ES 的 55.9%和 DC 的 64.35%的病历中记录了既往全身疾病。在 ES 记录中，47.45%包含用于治疗全身疾病的连续使用药物的信息，而 DC 记录中有 59.40%包含此类信息。共发现 359 个潜在的相互作用。与镇痛药的药物相互作用最常见，占样本的 50.41%。
最常见的药物相互作用严重程度为 2 级：监测或谨慎使用。许多患者服用药物来治疗全身疾病并寻求牙科护理，这可能会产生大量潜在的药物相互作用。
处方者必须仔细分析患者的病史，并准确获取有关其用药情况的数据，以便能够评估可能组合的风险效益关系。
