Department of Food Quality Control and Analysis, Muş Alparslan University, Muş, Turkey.
Department of Medical Biology and Genetics, Ankara Medipol University, Ankara, Turkey.
Arch Microbiol. 2022 Aug 5;204(9):541. doi: 10.1007/s00203-022-03154-8.
Numerous in-depth studies continue to reveal the many benefits of gut microbiota and young blood plasma administration. Dysbiosis, which occurs in the intestinal microbiota, especially in the aging process, is associated with many metabolic and cognitive disorders. Therefore, many studies aim to reverse the dysbiosis that occurs. There are also studies showing that young blood plasma application reverses the effects of aging at the level of many tissues and organs. Today, while research continues to reveal all the benefits of young blood plasma application in terms of health, blood plasma centers are also being established. In this study, we aimed to reveal the impact of young blood plasma, administered for 1 month, on the intestinal microbiota of middle-aged rats. After detailed metagenome analysis, alpha diversity indices demonstrated greater bacterial richness in the microbiota of plasma-administered rats compared with control rats. In addition, the Firmicutes/Bacteroidetes ratio was significantly diminished in plasma group microbiota, confirming possible rejuvenation properties of young plasma. Furthermore, increased counts of Bifidobacterium longum, Coprococcus catus, and Romboutsia ilealis species were measured in plasma-administered rats. The study revealed many fluctuations in different bacterial taxonomic units of the microbiota that could be valuable in future research on blood-based anti-aging treatments.
大量深入的研究不断揭示肠道微生物群和年轻血浆给药的诸多益处。肠道微生物群中出现的生态失调，特别是在衰老过程中，与许多代谢和认知障碍有关。因此，许多研究旨在逆转发生的生态失调。也有研究表明，年轻血浆的应用可以在许多组织和器官水平上逆转衰老的影响。如今，虽然研究继续揭示年轻血浆应用在健康方面的所有益处，但也在建立血浆中心。在这项研究中，我们旨在揭示给予 1 个月的年轻血浆对中年大鼠肠道微生物群的影响。经过详细的宏基因组分析，α多样性指数表明，接受血浆治疗的大鼠的微生物群中细菌丰富度更高。此外，血浆组微生物群中的厚壁菌门/拟杆菌门比值显著降低，证实了年轻血浆可能具有返老还童的特性。此外，在接受血浆治疗的大鼠中测量到长双歧杆菌、粪球菌和罗姆布茨氏菌属的数量增加。该研究揭示了微生物群中不同细菌分类单元的许多波动，这些波动在未来基于血液的抗衰老治疗的研究中可能具有价值。
