Peitl Vjekoslav, Getaldić-Švarc Biserka, Karlović Dalibor
Department of Psychiatry, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia.
Croatia and Catholic University of Croatia, Zagreb, Croatia.
Psychiatry Investig. 2020 Jun;17(6):579-586. doi: 10.30773/pi.2020.0033. Epub 2020 Jun 3.
Impaired serotonergic neurotransmission has been implicated in the pathogenesis of depression and schizophrenia. Blood platelets have been used for years as a peripheral model of neuronal serotonin dynamics. The objective was to investigate platelet count and serotonin concentration in patients with depression and schizophrenia, in an attempt to ascertain their clinical usefulness.
953 participants were included in the study, 329 patients with depression, 339 patients with schizophrenia and 285 healthy controls. ELISA was used to assess platelet serotonin concentrations.
There were no statistically significant differences among groups regarding age, total platelet count and serotonin concentration. Linear regression analyses revealed inverse correlations between platelet serotonin concentration and age of patients with depression and healthy individuals, as well as between platelet serotonin concentration and illness duration in patients with schizophrenia. In other words, longer illness duration in patients with schizophrenia, and higher age in patients with depression and healthy individuals was associated with lower platelet serotonin concentrations.
Platelet count and serotonin concentration did not prove to be of diagnostic value in differentiating patients and healthy individuals. However, illness duration in patients with schizophrenia may be associated with reduced concentrations of platelet serotonin.
血清素能神经传递受损与抑郁症和精神分裂症的发病机制有关。多年来，血小板一直被用作神经元血清素动态变化的外周模型。本研究旨在调查抑郁症和精神分裂症患者的血小板计数和血清素浓度，以确定其临床应用价值。
953名参与者纳入本研究，其中329名抑郁症患者、339名精神分裂症患者和285名健康对照者。采用酶联免疫吸附测定法评估血小板血清素浓度。
各组之间在年龄、血小板总数和血清素浓度方面无统计学显著差异。线性回归分析显示，抑郁症患者和健康个体的血小板血清素浓度与年龄之间呈负相关，精神分裂症患者的血小板血清素浓度与病程之间也呈负相关。换句话说，精神分裂症患者病程越长，抑郁症患者和健康个体年龄越大，血小板血清素浓度越低。
血小板计数和血清素浓度在区分患者和健康个体方面未显示出诊断价值。然而，精神分裂症患者的病程可能与血小板血清素浓度降低有关。
