Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Microb Genom. 2022 Aug;8(8). doi: 10.1099/mgen.0.000860.
Approximately 200 O-serogroups of have already been identified; however, only 2 serogroups, O1 and O139, are strongly related to pandemic cholera. The study of non-O1 and non-O139 strains has hitherto been limited. Nevertheless, there are other clinically and epidemiologically important serogroups causing outbreaks with cholera-like disease. Here, we report a comprehensive genome analysis of the whole set of O-serogroup reference strains to provide an overview of this important bacterial pathogen. It revealed structural diversity of the O-antigen biosynthesis gene clusters located at specific loci on chromosome 1 and 16 pairs of strains with almost identical O-antigen biosynthetic gene clusters but differing in serological patterns. This might be due to the presence of O-antigen biosynthesis-related genes at secondary loci on chromosome 2.
已经鉴定出大约 200 种 O 血清群的 ；然而，只有 2 个血清群，O1 和 O139，与大流行霍乱密切相关。对非-O1 和非-O139 菌株的研究迄今为止受到限制。然而，还有其他临床上和流行病学上重要的血清群引起类似霍乱的疾病爆发。在这里，我们报告了整个 O 血清群参考菌株的全基因组分析，为这一重要的细菌病原体提供了一个概述。它揭示了位于染色体 1 和 16 对菌株上特定位置的 O-抗原生物合成基因簇的结构多样性，这些菌株具有几乎相同的 O-抗原生物合成基因簇，但在血清学模式上有所不同。这可能是由于染色体 2 上的次要位置存在 O-抗原生物合成相关基因。
