Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques, Centre National de Référence Vibrions et Choléra, Paris, France.
ATCC, 10801 University Boulevard, Manassas, VA 20110, USA.
Microb Genom. 2024 Sep;10(9). doi: 10.1099/mgen.0.001282.
Several authors have attributed the explosive outbreak of gastroenteritis that occurred in Czechoslovakia in 1965 to a toxigenic strain of serogroup O37 based on unverified metadata associated with three particular strains from the American Type Culture Collection. Here, by sequencing the original strain preserved at the Czech National Collection of Type Cultures since 1966, we show that the strain responsible for this outbreak was actually a O5 that lacks the genes encoding the cholera toxin, the toxin-coregulated pilus protein and pathogenicity islands present in O37 strains.
几位作者将 1965 年捷克斯洛伐克发生的肠胃炎爆发归因于血清型 O37 的产毒菌株，这是基于与美国典型培养物保藏中心的三个特定菌株相关的未经证实的元数据。在这里，通过对自 1966 年以来保存在捷克国家典型培养物收藏中的原始菌株进行测序，我们表明，引起此次爆发的菌株实际上是 O5，它缺乏编码霍乱毒素、毒素调节菌毛蛋白和 O37 菌株中存在的致病岛的基因。
