Children's Hospital Colorado and the University of Colorado School of Medicine, Aurora, Colorado.
Obstet Gynecol. 2022 Sep 1;140(3):514-517. doi: 10.1097/AOG.0000000000004885. Epub 2022 Aug 3.
Nonsexually acquired genital ulcers have been described among girls who are prepubertal after various viral illnesses due to mucosal inflammation from an immunologic response. Until recently, nonsexually acquired genital ulcers have only been associated with viral infections.
We present a case of an adolescent girl developing nonsexually acquired genital ulcers after both her first and second coronavirus disease 2019 (COVID-19) vaccine doses. Her course followed an expected timeline for severity and resolution of ulcers.
Aphthous ulcers may arise from inflammatory effects of COVID-19 vaccination. Clinical monitoring after COVID-19 vaccination from all formulations should include assessment for nonsexually acquired genital ulcers if vaginal pain is reported.
在各种病毒性疾病后，由于免疫反应引起的黏膜炎症，青春期前的女童出现了非性传播的生殖器溃疡。直到最近，非性传播的生殖器溃疡才仅与病毒感染有关。
我们报告了一例青少年女孩在接种第一剂和第二剂 2019 冠状病毒病（COVID-19）疫苗后出现非性传播的生殖器溃疡。她的病程符合溃疡严重程度和愈合的预期时间。
阿弗他溃疡可能是 COVID-19 疫苗接种的炎症作用所致。对于所有剂型的 COVID-19 疫苗接种后，应进行临床监测，如果报告阴道疼痛，应评估是否出现非性传播的生殖器溃疡。
