University of Nebraska Medical Center, Children's Hospital and Medical Center, Omaha, Nebraska.
University of Nebraska Medical Center, Children's Hospital and Medical Center, Omaha, Nebraska.
J Pediatr Adolesc Gynecol. 2022 Apr;35(2):165-166. doi: 10.1016/j.jpag.2021.10.007. Epub 2021 Oct 28.
In this case report, we describe a potential association between the Pfizer-BioNTech COVID-19 vaccine and development of a vulvar aphthous ulcer in a virginal 14-year-old girl.
A 14-year-old patient reported vulvar pain and visible lesion. Exam findings were consistent with vulvar aphthous ulcers. Two days prior to the onset of her symptoms she received her second Pfizer-BioNTech COVID-19 vaccine. The evening of vaccine administration, she experienced several hours duration of fatigue, muscle aching and insomnia but had otherwise been recently healthy and testing for common viral associations of vulvar ulcers was negative.
Vaccination, in general, has been associated with mucosal side-effects and oral ulceration has been reported in subjects who received Pfizer-BioNTech COVID-19 vaccine. It is reasonable to hypothesize that vulvar ulceration may be caused by a similar mechanism and should be considered a rare side effect of this vaccine.
在本病例报告中，我们描述了辉瑞-生物技术公司的 COVID-19 疫苗与一名处女 14 岁女孩发生外阴阿弗他溃疡之间的潜在关联。
一名 14 岁患者报告外阴疼痛和可见损伤。检查结果符合外阴阿弗他溃疡。在出现症状前两天，她接种了第二剂辉瑞-生物技术公司的 COVID-19 疫苗。接种疫苗的当天晚上，她经历了数小时的疲劳、肌肉疼痛和失眠，但除此之外，她一直很健康，且常见的与外阴溃疡相关的病毒检测呈阴性。
一般来说，接种疫苗与粘膜副作用有关，接受辉瑞-生物技术公司 COVID-19 疫苗的患者也有报道出现口腔溃疡。合理假设外阴溃疡可能是由类似的机制引起的，应将其视为这种疫苗的罕见副作用。
