Faculty of Medicine, University of Peru for Applied Science, Lima, Peru.
Faculty of Medicine, National University of Trujillo, Trujillo, Peru.
Medwave. 2023 Mar 10;23(2). doi: 10.5867/medwave.2023.02.2674.
Lipschütz ulcer is a non-sexually transmitted genital lesion of unknown etiology, which presents as a painful vulvar ulcer. Lipschütz ulcers have been described in most continents. This is the first case reported in Peru and South America. We present the case of a 33-year-old female patient with a Lipschütz ulcer after being vaccinated with the second dose of the AstraZeneca COVID-19 vaccine. She reported having had only one sexual partner in her lifetime. Laboratory results were negative for herpes simplex 2, Cytomegalovirus, Toxoplasma gondii, Epstein-Barr virus, and syphilis. The patient received symptomatic treatment. Ten days after the onset, the patient was significantly better during follow-up. This case report displays a potential adverse effect of the AstraZeneca COVID-19 vaccine as a Lipschütz ulcer triggered by the host humoral immune response. However, further research is needed to establish the causal relationship between these two.
利普舒茨溃疡是一种病因不明的非性传播生殖器病变，表现为疼痛性外阴溃疡。利普舒茨溃疡已在各大洲被描述。这是在秘鲁和南美洲首例报告。我们报告了一例 33 岁女性患者，在接种阿斯利康 COVID-19 疫苗第二剂后出现利普舒茨溃疡。她报告一生中只有一个性伴侣。实验室结果为单纯疱疹 2 型、巨细胞病毒、弓形体、爱泼斯坦-巴尔病毒和梅毒均为阴性。患者接受了对症治疗。发病后 10 天，患者在随访中明显好转。本病例报告显示阿斯利康 COVID-19 疫苗的潜在不良反应，即由宿主体液免疫反应引发的利普舒茨溃疡。然而，需要进一步研究以确定这两者之间的因果关系。
