Gagnon R, Adkar V, Kaye M
Artif Organs. 1987 Apr;11(2):132-6. doi: 10.1111/j.1525-1594.1987.tb02644.x.
Dialysis patients are at risk for toxicity from formaldehyde used in the reprocessing of dialyzers for reuse; therefore, replacing formaldehyde as a dialyzer sterilant would be advantageous. The potential for RenNew-D as a sterilizing agent was investigated in seven stable in-center hemodialysis patients over 20 consecutive dialyses with cuprammonium cellulose hollow-fiber dialyzers. Treatment with RenNew-D showed no toxicity to patients or dialyzers except for two blood leaks occurring in one patient. The mean number of dialyzer uses was 4.9. In all the dialyzers that passed functional testing small solute clearances were maintained with reuse. The ability of RenNew-D to improve the biocompatibility of reused dialyzers was documented with mean neutrophil counts falling to only 78% of initial values during first reuse of dialyzers processed with RenNew-D compared with a decrease in neutrophil count to 2% of initial values during first use of the same dialyzers. Our results suggest that RenNew-D may be a useful alternative to formaldehyde for the purpose of dialyzer reuse. A reuse procedure that includes processing with RenNew-D is associated with improved biocompatibility, possibly because of maintenance of the blood-derived membrane coating established during prior dialysis.
透析患者面临着因用于复用透析器的甲醛而产生毒性的风险；因此，用其他物质替代甲醛作为透析器消毒剂将是有益的。对7名稳定的中心血液透析患者使用铜氨纤维素中空纤维透析器进行了连续20次透析，研究了RenNew-D作为消毒剂的潜力。使用RenNew-D进行治疗，除了1名患者出现2次血液渗漏外，对患者和透析器均未显示出毒性。透析器的平均使用次数为4.9次。在所有通过功能测试的透析器中，复用后小溶质清除率得以维持。在用RenNew-D处理的透析器首次复用期间，中性粒细胞平均计数仅降至初始值的78%，而相同透析器首次使用时中性粒细胞计数降至初始值的2%，这证明了RenNew-D能够改善复用透析器的生物相容性。我们的结果表明，RenNew-D可能是甲醛用于透析器复用的一种有用替代品。包括用RenNew-D处理的复用程序与生物相容性的改善有关，这可能是由于维持了先前透析期间形成的源自血液的膜涂层。
