Gagnon R F, Kaye M
Uremia Invest. 1984;8(1):17-23. doi: 10.3109/08860228409080978.
As part of a study to evaluate the safety and efficacy of dialyzer reuse, a comparative study of two methods of dialyzer reprocessing, manual and automated, was conducted. Five stable end-stage renal disease patients on center hemodialysis were evaluated as to hematological and metabolic parameters throughout two series of three consecutive dialyses using first new and then reused dialyzers reprocessed according to each of the two methods. New dialyzers and reused dialyzers following automated reprocessing always induced a profound fall in circulating neutrophil counts shortly after the start of dialysis. Hemodialysis neutropenia was not observed, however, with reused dialyzers reprocessed manually unless the concentration of sodium hypochlorite (bleach) employed was made equal to that required in automated reprocessing by being raised from 1.0 to 4.3%. It would be reasonable to conclude from these results that among the various differences between the two dialyzer reprocessing methods, restoration of the original level of biocompatibility of the reused dialyzer's membrane is related to the concentration of the cleansing agent.
作为一项评估透析器复用安全性和有效性研究的一部分，开展了一项关于两种透析器再处理方法（手动和自动）的对比研究。选取了五名接受中心血液透析的稳定终末期肾病患者，在两个连续的系列透析中，每个系列包含三次连续透析，首先使用新透析器，然后使用根据两种方法各自再处理后的复用透析器，评估其血液学和代谢参数。自动再处理后的新透析器和复用透析器在透析开始后不久总会导致循环中性粒细胞计数大幅下降。然而，手动再处理的复用透析器未观察到血液透析性中性粒细胞减少，除非将使用的次氯酸钠（漂白剂）浓度从1.0%提高到4.3%，使其与自动再处理所需的浓度相同。从这些结果可以合理推断，在两种透析器再处理方法的各种差异中，复用透析器膜生物相容性原始水平的恢复与清洗剂浓度有关。
