Shively C A, Clarkson T B, Miller L C, Weingand K W
Arteriosclerosis. 1987 May-Jun;7(3):226-31. doi: 10.1161/01.atv.7.3.226.
Central fat deposition is associated with increased risk of coronary heart disease morbidity and mortality in women. Subcutaneous fat distribution was investigated as a potential factor that might exacerbate diet-induced coronary artery atherosclerosis (CAA) in female cynomolgus monkeys (Macaca fascicularis) which share with North American Caucasian women a gender-related protection against CAA. In a retrospective necropsy study (n = 36), the distribution of the antemortem ratio of subscapular/triceps skinfold thickness was divided at the mean and the two resulting groups were designated high and low for this variable. CAA was quantified as the mean cross-sectional intimal area based on nine coronary artery sections. The extent of CAA was significantly greater in the high skinfold ratio group as compared to the low skinfold ratio group. Ponderosity was closely associated with the skinfold ratio but was not a useful predictor of CAA. These findings suggest that female cynomolgus macaques may provide a primate model of the health consequences of regional fat distribution in women.
中心性脂肪沉积与女性冠心病发病率和死亡率的增加有关。皮下脂肪分布被作为一个潜在因素进行研究，该因素可能会加剧食源性冠状动脉粥样硬化（CAA），在与北美白人女性一样具有与性别相关的CAA防护能力的雌性食蟹猴（猕猴属）中。在一项回顾性尸检研究（n = 36）中，将肩胛下/三头肌皮褶厚度的生前比率分布按均值进行划分，由此产生的两组分别被指定为该变量的高值组和低值组。CAA被量化为基于九个冠状动脉切片的平均横截面内膜面积。与低值皮褶比率组相比，高值皮褶比率组的CAA程度显著更高。肥胖与皮褶比率密切相关，但不是CAA的有效预测指标。这些发现表明，雌性食蟹猴可能为女性局部脂肪分布对健康影响提供一个灵长类动物模型。
