用卟啉衍生物中-四（4-N-甲基吡啶基）卟吩对染色质荧光反应的细胞化学研究
Cytochemical study of the fluorescence reaction of chromatin by the porphyrin derivative meso-tetra (4-N-methylpyridyl) porphine.
作者信息
Villanueva A, Cañete M, Juarranz A, Stockert J C
出版信息
Basic Appl Histochem. 1987;31(1):9-16.
PMID:3593176
Abstract
Application of meso-tetra (4-N-methylpyridyl) porphine (TMPP) on smears of chicken blood revealed an intense red fluorescence on the nuclei under blue-violet exciting light, which seemed to be dependent on the DNA component of chromatin. The possibility that an intercalative binding mechanism based on hydrophobic interaction occurs between TMPP molecules and paired bases of DNA is briefly discussed.
摘要
中-四（4-N-甲基吡啶基）卟啉（TMPP）应用于鸡血涂片上，在蓝紫光激发光下细胞核呈现强烈的红色荧光，这似乎取决于染色质的DNA成分。本文简要讨论了TMPP分子与DNA配对碱基之间基于疏水相互作用的插入结合机制的可能性。
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